Evidence map›Paper›PMID 24570664›Full record

ReviewFrontiers in psychology2014

The influences of age on olfaction: a review.

Richard L Doty, Vidyulata Kamath

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in psychology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04617444 (Substudy of Efficacy, Safety and Toxicology of Electronic Nicotine Delivery Systems as an Aid for Smoking Cessation), which is not on this map. Cited by 289 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
289citing papers in PubMed, 7 pooled it
21.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04617444 nacompletednot on this mapstarted 2020, after this paper: background citation

Substudy of Efficacy, Safety and Toxicology of Electronic Nicotine Delivery Systems as an Aid for Smoking Cessation (ESTxENDS Trial)- the Olfactory Function Substudy of ESTxENDS

TypeinterventionalSponsorUniversity of BernRan2020 to 2023Enrolled389ConditionsSmoking Cessation, Olfactory DisorderArmsENDS (vaporizer/e-cig) and smoking cessation counseling, Smoking cessation counseling
3 · Its place in the literature

Who cites it

289 citing papers in PubMed, 7 syntheses or guidelines pooled it, 606 citations in OpenAlex.

  1. The efficacy of olfactory training in improving olfactory function: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
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  12. A new framework for the labeling of odors in the Sniffin' Sticks odor identification test: relevance of familiarity and test-retest assessment.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  16. Progress of Immunotherapies in Parkinson's Disease.CNS neuroscience & therapeutics · 2026
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229 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Richard L DotyDepartment of Otorhinolaryngology: Head and Neck Surgery, Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA.
Vidyulata KamathDepartment of Otorhinolaryngology: Head and Neck Surgery, Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania Philadelphia, PA, USA ; Division of Medical Psychology, Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine Baltimore, MD, USA.
Taste and Smell Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decreased olfactory function is very common in the older population, being present in over half of those between the ages of 65 and 80 years and in over three quarters of those over the age of 80 years. Such dysfunction significantly influences physical well-being and quality of life, nutrition, the enjoyment of food, as well as everyday safety. Indeed a disproportionate number of the elderly die in accident gas poisonings each year. As described in this review, multiple factors contribute to such age-related loss, including altered nasal engorgement, increased propensity for nasal disease, cumulative damage to the olfactory epithelium from viral and other environmental insults, decrements in mucosal metabolizing enzymes, ossification of cribriform plate foramina, loss of selectivity of receptor cells to odorants, changes in neurotransmitter and neuromodulator systems, and neuronal expression of aberrant proteins associated with neurodegenerative disease. It is now well established that decreased smell loss can be an early sign of such neurodegenerative diseases as Alzheimer's disease and sporadic Parkinson's disease. In this review we provide an overview of the anatomy and physiology of the aging olfactory system, how this system is clinically evaluated, and the multiple pathophysiological factors that are associated with its dysfunction.

Indexed as

ageAlzheimer's diseaseanatomyneurodegenerationolfactionParkinson's diseasephysiologypsychophysics

Identifiers

PMID24570664
PMCPMC3916729
OpenAlexW2168835104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.