ReviewFrontiers in neuroscience2014
Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis.
Review in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Neurogenic Fever after Subarachnoid Hemorrhage in Animal Models: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Gut microbiota, brown adipose tissue whitening, and obesity: nutritional modulators and metabolic crosstalk.Nutrition & metabolism · 2026Review
- Thermoregulatory Dysfunction in Parkinson's Disease: Mechanisms, Implications, and Therapeutic Perspectives.Cells · 2025Review
- The role of brown adipose tissue in mediating healthful longevity.The journal of cardiovascular aging · 2024Article
- Activation of orexin-A (hypocretin-1) receptors in the Raphe Pallidus at different ambient temperatures in the rat: effects on thermoregulation, cardiovascular control, sleep, and feeding behavior.Frontiers in neuroscience · 2024Article
- Metabolic Disorders, the Microbiome as an Endocrine Organ, and Their Relations with Obesity: A Literature Review.Journal of personalized medicine · 2023Review
- SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice.Nature communications · 2022Article
- Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency.The Journal of clinical investigation · 2022Article
- Possible roles of exercise and apelin against pregnancy complications.Frontiers in endocrinology · 2022Review
- Experimental Applications and Factors Involved in Validating Thermal Windows Using Infrared Thermography to Assess the Health and Thermostability of Laboratory Animals.Animals : an open access journal from MDPI · 2021Review
- The Arcuate Nucleus of the Hypothalamus and Metabolic Regulation: An Emerging Role for Renin-Angiotensin Pathways.International journal of molecular sciences · 2021Review
- In a model of SAH-induced neurogenic fever, BAT thermogenesis is mediated by erythrocytes and blocked by agonism of adenosine A1 receptors.Scientific reports · 2021Article
- Central Apolipoprotein A-IV Stimulates Thermogenesis in Brown Adipose Tissue.International journal of molecular sciences · 2021Article
- Discrete TrkB-expressing neurons of the dorsomedial hypothalamus regulate feeding and thermogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Median preoptic area neurons are required for the cooling and febrile activations of brown adipose tissue thermogenesis in rat.Scientific reports · 2020Article
- DUODENAL-JEJUNAL BYPASS REDUCES LIPID ACCUMULATION IN THE BROWN ADIPOSE TISSUE OF HYPOTHALAMIC OBESE RATS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2020Article
- Intrinsic expression of viperin regulates thermogenesis in adipose tissues.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes.Journal of physiology and biochemistry · 2019Review
- Preoptic area cooling increases the sympathetic outflow to brown adipose tissue and brown adipose tissue thermogenesis.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
From mouse to man, brown adipose tissue (BAT) is a significant source of thermogenesis contributing to the maintenance of the body temperature homeostasis during the challenge of low environmental temperature. In rodents, BAT thermogenesis also contributes to the febrile increase in core temperature during the immune response. BAT sympathetic nerve activity controlling BAT thermogenesis is regulated by CNS neural networks which respond reflexively to thermal afferent signals from cutaneous and body core thermoreceptors, as well as to alterations in the discharge of central neurons with intrinsic thermosensitivity. Superimposed on the core thermoregulatory circuit for the activation of BAT thermogenesis, is the permissive, modulatory influence of central neural networks controlling metabolic aspects of energy homeostasis. The recent confirmation of the presence of BAT in human and its function as an energy consuming organ have stimulated interest in the potential for the pharmacological activation of BAT to reduce adiposity in the obese. In contrast, the inhibition of BAT thermogenesis could facilitate the induction of therapeutic hypothermia for fever reduction or to improve outcomes in stroke or cardiac ischemia by reducing infarct size through a lowering of metabolic oxygen demand. This review summarizes the central circuits for the autonomic control of BAT thermogenesis and highlights the potential clinical relevance of the pharmacological inhibition or activation of BAT thermogenesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.