ArticleAnnals of biomedical engineering2014
Oxygen-tension controlled matrices for enhanced osteogenic cell survival and performance.
Article in Annals of biomedical engineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Decellularized cartilage tissue bioink formulation for osteochondral graft development.Biomedical materials (Bristol, England) · 2025Article
- Decellularized Tissue-Induced Cellular Recruitment for Tissue Engineering and Regenerative Medicine.Annals of biomedical engineering · 2024Article
- Nondestructive, longitudinal, 3D oxygen imaging of cells in a multi-well plate using pulse electron paramagnetic resonance imaging.Npj imaging · 2024Article
- Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects.Bioactive materials · 2024Review
- Smart Orthopedic Biomaterials and Implants.Current opinion in biomedical engineering · 2023Article
- Amorphous silica fiber matrix biomaterials: An analysis of material synthesis and characterization for tissue engineering.Bioactive materials · 2023Article
- Harnessing mechanical cues in the cellular microenvironment for bone regeneration.Frontiers in physiology · 2023Review
- Biomaterial-directed cell behavior for tissue engineering.Current opinion in biomedical engineering · 2021Article
- Evaluation of Autologously Derived Biomaterials and Stem Cells for Bone Tissue Engineering.Tissue engineering. Part A · 2020Article
- 3D-Printing of Hierarchically Designed and Osteoconductive Bone Tissue Engineering Scaffolds.Materials (Basel, Switzerland) · 2020Article
- Evaluation of an Engineered Hybrid Matrix for Bone Regeneration via Endochondral Ossification.Annals of biomedical engineering · 2020Article
- From skeletal development to the creation of pluripotent stem cell-derived bone-forming progenitors.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Noninvasive Absolute Electron Paramagnetic Resonance Oxygen Imaging for the Assessment of Tissue Graft Oxygenation.Tissue engineering. Part C, Methods · 2018Article
- Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering.Advanced drug delivery reviews · 2016Review
- Oxygen Tension-Controlled Matrices with Osteogenic and Vasculogenic Cells for Vascularized Bone Regeneration In Vivo.Tissue engineering. Part A · 2016Article
- Bone Tissue Engineering with Multilayered Scaffolds-Part I: An Approach for Vascularizing Engineered Constructs In Vivo.Tissue engineering. Part A · 2015Article
- Biomaterials for Bone Regenerative Engineering.Advanced healthcare materials · 2015Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The success of a clinically-applicable bone tissue engineering construct for large area bone defects depends on its ability to allow for homogeneous bone regeneration throughout the construct. Insufficient vascularization, and consequently inadequate oxygen tension, throughout constructs has been largely cited as the most significant obstacle facing successful bone regeneration in large area defects. The development of constructs that support bone and vessel-forming cell growth and function throughout the scaffold structure are desired for large-area bone defect repair. Here, we developed oxygen tension-controlled matrices that support more homogenous oxygen levels throughout the constructs. Specifically, we examined polylactic co-glycolic acid (PLGA) scaffolds with optimized pore distribution and the percent pore volumes, and demonstrated significantly decreased oxygen and pH gradient from the exterior of the construct to the interior after long-term cell culture in vitro. We confirmed the ability of these optimized constructs to support the cellular survival via live/dead assay. In addition, we examined their ability to support the maintenance of two clinically relevant progenitor cell populations for bone tissue engineering and vascularization, namely mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs), and confirmed the expression of key bone and vascular markers via immunofluorescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.