Evidence map›Paper›PMID 24570267›Full record

ArticleIntensive care medicine2014

Cardiopulmonary resuscitation among mechanically ventilated patients.

Ali Al-Alwan, William J Ehlenbach, Prema R Menon, Michael P Young, Renee D Stapleton

Registry-linked trialAbstract read
In one paragraph

Article in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02790788 (Physiologic Effects of Stress Dose Corticosteroids in the Management of Inhospital Cardiac Arrest - CORTICA), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02790788 phase1 / phase2completednot on this mapstarted 2016, after this paper: background citation

Physiologic Effects of Stress Dose Corticosteroids in the Management of Inhospital Cardiac Arrest - CORTICA

TypeinterventionalSponsorUniversity of AthensRan2016 to 2018Enrolled100ConditionsInhospital Cardiac ArrestArmsMethylprednisolone, hydrocortisone, Saline Placebo
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. How to discuss about do-not-resuscitate in the intensive care unit?Revista Brasileira de terapia intensiva · 2019
    Review
  6. Article
  7. Focus on cardiac arrest.Intensive care medicine · 2016
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Ali Al-AlwanSeacoast Pulmonary Medicine, Wentworth-Douglass Hospital, 789 Central Avenue, Dover, NH, 03820, USA.
William J Ehlenbach
Prema R Menon
Michael P Young
Renee D Stapleton
University of Vermont · USAtrium Health Wake Forest Baptist · USUniversity of Wisconsin–Madison · USWentworth Douglass Hospital · US

Funding

WEIGHT LOSS & ASTHMAP20RR015557 · NCRR · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI RINCON, MERCEDES · 2000 to 2009
$21.4M
UW Multidisciplinary Clinical Research Training (RMI)K12RR023265 · NCRR · UNIVERSITY OF WASHINGTON · PI PROBSTFIELD, JEFFREY LYNN · 2005 to 2007
$6.1M
Multidisciplinary Training in Lung BiologyT32HL076122 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI IRVIN, CHARLES G, POYNTER, MATTHEW E · 2004 to 2023
$6.1M
Cognitive outcomes and neuropathology in older adults following critical illnessK23AG038352 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI EHLENBACH, WILLIAM JOSEPH · 2011 to 2015
$759k
NCRR NIH HHS 5P20RR015557NCRR NIH HHS 8K12RR023265NCRR NIH HHS K12 RR023265NCRR NIH HHS P20 RR015557NHLBI NIH HHS T32 HL076122NHLBI NIH HHS T32HL076122NIA NIH HHS 5K23AG038352NIA NIH HHS K23 AG038352
6 · The paper itself

Abstract

purposeTo evaluate the outcomes, including long-term survival, after cardiopulmonary resuscitation (CPR) in mechanically ventilated patients.

methodsWe analyzed Medicare data from 1994 to 2005 to identify beneficiaries who underwent in-hospital CPR. We then identified a subgroup receiving CPR one or more days after mechanical ventilation was initiated [defined by ICD-9 procedure code for intubation (96.04) or mechanical ventilation (96.7x) one or more days prior to procedure code for CPR (99.60 or 99.63)].

resultsWe identified 471,962 patients who received in-hospital CPR with an overall survival to hospital discharge of 18.4 % [95 % confidence interval (CI) 18.3-18.5 %]. Of those, 42,163 received CPR one or more days after mechanical ventilation initiation. Survival to hospital discharge after CPR in ventilated patients was 10.1 % (95 % CI 9.8-10.4 %), compared to 19.2 % (95 % CI 19.1-19.3 %) in non-ventilated patients (p < 0.001). Among this group, older age, race other than white, higher burden of chronic illness, and admission from a nursing facility were associated with decreased survival in multivariable analyses. Among all CPR recipients, those who were ventilated had 52 % lower odds of survival (OR 0.48, 95 % CI 0.46-0.49, p < 0.001). Median long-term survival in ventilated patients receiving CPR who survived to hospital discharge was 6.0 months (95 % CI 5.3-6.8 months), compared to 19.0 months (95 % CI 18.6-19.5 months) among the non-ventilated survivors (p < 0.001 by logrank test). Of all patients receiving CPR while ventilated, only 4.1 % were alive at 1 year.

conclusionsSurvival after in-hospital CPR is decreased among ventilated patients compared to those who are not ventilated. This information is important for clinicians, patients, and family members when discussing CPR in critically ill patients.

Indexed as

Cardiopulmonary ResuscitationRespiration, ArtificialAdolescentAdultAgedAged, 80 and overChronic DiseaseCost of IllnessFemaleHumansMaleMiddle AgedMultivariate AnalysisRacial GroupsTreatment Outcome

Identifiers

PMID24570267
PMCPMC4005593
OpenAlexW2002413154

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.