ReviewIntensive care medicine2014
Medical research in emergency research in the European Union member states: tensions between theory and practice.
Review in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- A qualitative feasibility study to inform a randomised controlled trial of fluid bolus therapy in septic shock.Archives of disease in childhood · 2018Trial
- Review
- Emergency research without prior consent in the United States, Canada, European Union and United Kingdom: How regulatory differences affect study design and implementation in cardiac arrest trials.Resuscitation plus · 2024Review
- Article
- Patient and proxies' attitudes towards deferred consent in randomised trials of acute treatment for stroke: A qualitative survey.European stroke journal · 2021Article
- [Ethics of resuscitation and end of life decisions].Notfall & rettungsmedizin · 2021Review
- Advances and challenges in conducting ethical trials involving populations lacking capacity to consent: A decade in review.Contemporary clinical trials · 2020Article
- Huge variation in obtaining ethical permission for a non-interventional observational study in Europe.BMC medical ethics · 2019Article
- Children's views on research without prior consent in emergency situations: a UK qualitative study.BMJ open · 2018Article
- Ethical challenges in resuscitation.Intensive care medicine · 2018Review
- Ethical challenges involved in obtaining consent for research from patients hospitalized in the intensive care unit.Annals of translational medicine · 2017Article
- Research in Emergency and Critical Care Settings: Debates, Obstacles and Solutions.Science and engineering ethics · 2016Review
- Hemodynamic assessment of ventilated ICU patients with cardiorespiratory failure using a miniaturized multiplane transesophageal echocardiography probe.Intensive care medicine · 2015Article
- Article
- Increasing participation in critical care studies: the need to understand surrogate decision-makers for critically ill patients.Intensive care medicine · 2015Article
- What's new in ethics of cardio-pulmonary resuscitation research: too little time and too many rules?Intensive care medicine · 2015Article
- Clinical research in emergency situations in incompetent persons: the situation in Italy.Intensive care medicine · 2014Article
- Clinical research in the ICU: response to Kompanje et al.Intensive care medicine · 2014Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
4 authors.
Funding
Abstract
In almost all of the European Union member states, prior consent by a legal representative is used as a substitute for informed patient consent for non-urgent medical research. Deferred (patient and/or proxy) consent is accepted as a substitute in acute emergency research in approximately half of the member states. In 12 European Union member states emergency research is not mentioned in national law. Medical research in the European Union is covered by the Clinical Trial Directive 2001/20/EC. A proposal for a regulation by the European Commission is currently being examined by the European Parliament and the Council and will replace Directive 2001/20/EC. Deferred patient and/or proxy consent is allowed in the proposed regulation, but does not fit completely in the practice of emergency research. For example, deferred consent is only possible when legal representatives are not available. This criterion will delay inclusion of patients in acute life-threatening conditions in short time frames. As the regulation shall be binding in its entirety in all member states, emergency research in acute situations is still not possible as it should be.
Indexed as
Identifiers
24570266What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.