ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2014
Treatment developments and the unfolding of the quality of life discussion in childhood medulloblastoma: a review.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- A Rare Case of Posterior Fossa Syndrome Associated with Neuropathic Pain Successfully Treated with a Combination of Gabapentin, Diazepam and Baclofen-A Case Report and Literature Review.Children (Basel, Switzerland) · 2024Article
- Evolution of neurosurgical advances and nuances in medulloblastoma therapy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Robustness and dosimetric verification of hippocampal-sparing craniospinal pencil beam scanning proton plans for pediatric medulloblastoma.Physics and imaging in radiation oncology · 2024Article
- Integrated analysis of multiple methods reveals characteristics of the immune microenvironment in medulloblastoma.Brain tumor pathology · 2023Article
- The reliability of the health related quality of life questionnaire PedsQL 3.0 cancer module in a sample of Swedish children.BMC pediatrics · 2020Article
- Posterior Fossa Society Consensus Meeting 2018: a synopsis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Cerebellar mutism syndrome: current approaches to minimize risk for CMS.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Childhood medulloblastoma-a single institution's historical perspective on survival and functional morbidity.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Impact of miRNA-mRNA Profiling and Their Correlation on Medulloblastoma Tumorigenesis.Molecular therapy. Nucleic acids · 2018Article
- Management and outcomes of treating pediatric medulloblastoma: an eight years' experience in an Iranian pediatric center.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Longitudinal assessment of late-onset neurologic conditions in survivors of childhood central nervous system tumors: a Childhood Cancer Survivor Study report.Neuro-oncology · 2018Article
- Childhood Medulloblastoma: Current Therapies, Emerging Molecular Landscape and Newer Therapeutic Insights.Current neuropharmacology · 2018Review
- Quality of life in long-term survivors treated for metastatic medulloblastoma with a hyperfractionated accelerated radiotherapy (HART) strategy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- Demographics, patterns of care, and survival in pediatric medulloblastoma.Journal of neuro-oncology · 2017Article
- Detection of lower levels of SNAP25 using multiple microarray systems and its functional significance in medulloblastoma.International journal of molecular medicine · 2017Article
- Article
- Medulloblastoma.Journal of child neurology · 2016Review
- Changes in Imaging and Cognition in Juvenile Rats After Whole-Brain Irradiation.International journal of radiation oncology, biology, physics · 2016Article
- Consensus paper on post-operative pediatric cerebellar mutism syndrome: the Iceland Delphi results.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Psychosocial profile of pediatric brain tumor survivors with neurocognitive complaints.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe how the quality of life (QOL) discussion in childhood medulloblastoma (MB) relates to treatment developments, survival and sequelae from 1920 to 2014.
methodsArticles containing "childhood medulloblastoma" and "quality of life" were identified in PubMed. Those containing phrases pertaining to psychological, emotional, behavioral or social adjustment in the title, abstract or keywords were selected. Inclusion of relevant older publications was assured by cross-checking references.
results1920-1930s: suction, electro-surgery, kilovolt (KV) irradiation. Survival = months. Focus on operative mortality, symptoms and survival. 1940s: radiotherapy improved. 1950s: chemotherapy and intubation. Survival = years. Opinions oscillated between optimism/awareness of physical sequelae of radiotherapy. 1960s: magnified vision, ventriculo-peritoneal (VP) shunts, megavolt (MV) irradiation. Long-term survival shifted the attention towards neurological problems, disability and carcinogenesis of radiotherapy. 1970s: CT, microscope, bipolar coagulation, shunt filters, neuroanesthesia, chemotherapy trials and staging studies. Operative mortality decreased and many patients (re)entered school; emphasis on neuropsychological sequelae, IQ and academic performance. 1980s: magnetic resonance imaging (MRI), Cavitron ultrasonic aspiration (CUSA), laser surgery, hyper-fractionated radiotherapy (HFRT). Cerebellar mutism, psychological and social issues. 1990s: pediatric neurosurgery, proton beams, stem cell rescue. Reflections on QOL as such. 21st century: molecular genetics. Premature aging, patterns of decline, risk- and resilience factors. DISCUSSION: QOL is a critical outcome measure. Focus depends on survival and sequelae, determined after years of follow-up. Detailed measurements are limited by time, money and human resources, and self-reporting questionnaires represent a crude measure limited by subjectivity. Therapeutic improvements raise the question of QOL versus cure. QOL is a potential primary research endpoint; multicenter international studies are needed, as are web-based tools that work across cultures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.