ReviewEnvironmental health perspectives2014
Non-renal effects and the risk assessment of environmental cadmium exposure.
Review in Environmental health perspectives, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 301 citations in OpenAlex.
- Evaluation of the association between urinary cadmium levels below threshold limits and the risk of diabetes mellitus: a dose-response meta-analysis.Environmental science and pollution research international · 2019Pooled it
- Blood levels of cadmium and lead in relation to breast cancer risk in three prospective cohorts.International journal of cancer · 2019Pooled it
- Low-Level Cadmium Exposure Is Associated With Decreased Bone Mineral Density and Increased Risk of Incident Fractures in Elderly Men: The MrOS Sweden Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Trial
- Cadmium exposure triggers a functional switch of APP to drive joint degeneration.Molecular medicine (Cambridge, Mass.) · 2026Article
- Heavy Metal Toxicity in Clinical and Environmental Health: Sources, Mechanisms, Diagnostics, and Evidence-Based Management of Mercury, Lead, Cadmium, and Arsenic.International journal of molecular sciences · 2026Review
- Assessment of Iron's Regulatory Impact on Cadmium Bioavailability in Rice-Based Diets Using a Mouse Model.Biological trace element research · 2026Article
- Understanding molecular mechanisms driving cadmium-induced mitochondrial dysfunction in human metabolic liver disease.Environmental toxicology and pharmacology · 2026Review
- Ecological and Human Health Risk Assessment of Metals in Peruvian Avocados Using a Probabilistic Approach.Foods (Basel, Switzerland) · 2025Article
- Article
- Cadmium toxicity, health risk and its remediation using low-cost biochar adsorbents.Open life sciences · 2025Review
- Review
- Cadmium and its inorganic compounds - Addendum: re-evaluation of the BLW: Assessment Values in Biological Material - Translation of the German version from 2025.The MAK collection for occupational health and safety · 2025Review
- Association of Urinary Cadmium Concentration With Cognitive Impairment in US Adults: A Longitudinal Cohort Study.Neurology · 2024Article
- Evaluation of cadmium effects on the glucose metabolism on insulin resistance HepG2 cells.Heliyon · 2024Article
- Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse andEnvironmental health perspectives · 2024Article
- A protocol for the prospective study of urinary cadmium with risk of fracture, bone loss, and muscle loss.JBMR plus · 2024Article
- A regional comparison of children's blood cadmium, lead, and mercury in rural, urban and industrial areas of six European countries, and China, Ecuador, and Morocco.International journal of occupational medicine and environmental health · 2023Article
- Transcriptomic and Functional Analyses of Two Cadmium Hyper-Enriched Duckweed Strains Reveal Putative Cadmium Tolerance Mechanisms.International journal of molecular sciences · 2023Article
- Multi-Element Assessment of Potentially Toxic and Essential Elements in New and Traditional Food Varieties in Sweden.Foods (Basel, Switzerland) · 2023Article
- Clinical features and shared mechanisms of chronic gastritis and osteoporosis.Scientific reports · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to cadmium (Cd) has long been recognized as a health hazard, both in industry and in general populations with high exposure. Under the currently prevailing health risk assessment, the relationship between urinary Cd (U-Cd) concentrations and tubular proteinuria is used. However, doubts have recently been raised regarding the justification of basing the risk assessment on this relationship at very low exposure.
objectivesOur objective was to review available information on health effects of Cd exposure with respect to human health risk assessment. DISCUSSION: The associations between U-Cd and urinary proteins at very low exposure may not be due to Cd toxicity, and the clinical significance of slight proteinuria may also be limited. More importantly, other effects have been reported at very low Cd exposure. There is reason to challenge the basis of the existing health risk assessment for Cd. Our review of the literature found that exposure to low concentrations of Cd is associated with effects on bone, including increased risk of osteoporosis and fractures, and that this observation has implications for the health risk assessment of Cd. Other effects associated with Cd should also be considered, in particular cancer, although the information is still too limited for appropriate use in quantitative risk assessment.
conclusionNon-renal effects should be considered critical effects in the health risk assessment of Cd.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.