ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2014
Dependence of phase-2 reentry and repolarization dispersion on epicardial and transmural ionic heterogeneity: a simulation study.
Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Phase 2 Re-Entry Without IJACC. Clinical electrophysiology · 2023Trial
- Modes of onset of ventricular arrhythmias in J-wave syndromes: mechanistic insights from computational modeling.American journal of physiology. Heart and circulatory physiology · 2026Article
- Intracellular ion accumulation in the genesis of complex action potential dynamics under cardiac diseases.Physical review. E · 2024Article
- Inherited Arrhythmias in the Pediatric Population: An Updated Overview.Medicina (Kaunas, Lithuania) · 2024Review
- Brugada syndrome update.Frontiers in physiology · 2024Review
- Brugada Syndrome: From Molecular Mechanisms and Genetics to Risk Stratification.International journal of molecular sciences · 2023Review
- The importance of mechanical conditions in the testing of excitation abnormalities in a population of electro-mechanical models of human ventricular cardiomyocytes.Frontiers in physiology · 2023Article
- R-on-T and the initiation of reentry revisited: Integrating old and new concepts.Heart rhythm · 2022Article
- Life and death saddles in the heart.Physical review. E · 2021Article
- Atrial Fibrillation in Inherited Channelopathies.Cardiac electrophysiology clinics · 2021Review
- The transient outward potassium current plays a key role in spiral wave breakup in ventricular tissue.American journal of physiology. Heart and circulatory physiology · 2021Article
- Absence of Rgs5 Influences the Spatial and Temporal Fluctuation of Cardiac Repolarization in Mice.Frontiers in physiology · 2021Article
- Transmural conduction time in an early repolarization syndrome model.Experimental and therapeutic medicine · 2020Article
- Small-conductance CaHeart rhythm · 2020Article
- Brugada syndrome: A comprehensive review of pathophysiological mechanisms and risk stratification strategies.International journal of cardiology. Heart & vasculature · 2020Review
- Memory-Induced Chaos in Cardiac Excitation.Physical review letters · 2017Article
- Icariin, a Novel Blocker of Sodium and Calcium Channels, Eliminates Early and Delayed Afterdepolarizations, As Well As Triggered Activity, in Rabbit Cardiomyocytes.Frontiers in physiology · 2017Article
- Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies.Frontiers in physiology · 2016Review
- Perspective: a dynamics-based classification of ventricular arrhythmias.Journal of molecular and cellular cardiology · 2015Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
aimsPhase-2 reentry (P2R) is a local arrhythmogenic phenomenon where electrotonic current propagates from a spike-and-dome action potential region to re-excite a loss-of-dome action potential region. While ionic heterogeneity has been shown to underlie P2R within the epicardium and has been hypothesized to occur transmurally, we are unaware of any study that has investigated the effects of combining these heterogeneities as they occur in the heart. Thus, we tested the hypothesis that P2R can result by either epicardial or transmural heterogeneity and that the realistic combination of the two would increase the likelihood of P2R. METHODS AND
resultsWe used computational ionic models of cardiac myocyte dynamics to investigate initiation and development of P2R in simulated tissues with different ionic heterogeneities. In one-dimensional transmural cable simulations, P2R occurred when the conductance of the transient outward current in the epicardial region was near the range for which epicardial action potentials switched intermittently between spike-and-dome and loss-of-dome morphologies. Phase-2 reentry was more likely in two-dimensional tissue simulations by both epicardial and transmural heterogeneity and could expand beyond its local initiation site to create a macroscopic reentry.
conclusionThe characteristics and stability of action potential morphology in the epicardium are important determinants of the occurrence of both transmural and epicardial P2R and its associated arrhythmogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.