ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2014
Mechanistic insights into hypothermic ventricular fibrillation: the role of temperature and tissue size.
Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Acetaminophen (Paracetamol) Induces Hypothermia During Acute Cold Stress.Clinical drug investigation · 2017Trial
- Clinical subphenotypes in septic patients with new-onset atrial fibrillation: validation and parsimonious classifier model development.BMC medical informatics and decision making · 2026Article
- Magnetic field based investigation of Brugada syndrome.European biophysics journal : EBJ · 2026Article
- A cross species thermoelectric and spatiotemporal analysis of alternans in live explanted hearts using dual voltage-calcium fluorescence optical mapping.Physiological measurement · 2024Article
- Article
- Thermal effects on cardiac alternans onset and development: A spatiotemporal correlation analysis.Physical review. E · 2021Article
- Electrophysiological Characterization of Human Atria: The Understated Role of Temperature.Frontiers in physiology · 2021Article
- Defibrillate You Later, Alligator: Q10 Scaling and Refractoriness Keeps Alligators from Fibrillation.Integrative organismal biology (Oxford, England) · 2021Article
- Therapeutic Hypothermia Reduces Peritoneal Dialysis Induced Myocardial Blood Flow Heterogeneity and Arrhythmia.Frontiers in medicine · 2021Article
- Simulating waves, chaos and synchronization with a microcontroller.Chaos (Woodbury, N.Y.) · 2019Article
- Large-scale Interactive Numerical Experiments of Chaos, Solitons and Fractals in Real Time via GPU in a Web Browser.Chaos, solitons, and fractals · 2019Article
- Article
- From ionic to cellular variability in human atrial myocytes: an integrative computational and experimental study.American journal of physiology. Heart and circulatory physiology · 2018Article
- Simultaneous Quantification of Spatially Discordant Alternans in Voltage and Intracellular Calcium in Langendorff-Perfused Rabbit Hearts and Inconsistencies with Models of Cardiac Action Potentials and Ca Transients.Frontiers in physiology · 2017Article
- Modeling hypothermia induced effects for the heterogeneous ventricular tissue from cellular level to the impact on the ECG.PloS one · 2017Article
- The Role of Transmural Repolarization Gradient in the Inversion of Cardiac Electric Field: Model Study of ECG in Hypothermia.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2017Article
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
aimsHypothermia is well known to be pro-arrhythmic, yet it has beneficial effects as a resuscitation therapy and valuable during intracardiac surgeries. Therefore, we aim to study the mechanisms that induce fibrillation during hypothermia. A better understanding of the complex spatiotemporal dynamics of heart tissue as a function of temperature will be useful in managing the benefits and risks of hypothermia. METHODS AND
resultsWe perform two-dimensional numerical simulations by using a minimal model of cardiac action potential propagation fine-tuned on experimental measurements. The model includes thermal factors acting on the ionic currents and the gating variables to correctly reproduce experimentally recorded restitution curves at different temperatures. Simulations are implemented using WebGL, which allows long simulations to be performed as they run close to real time. We describe (i) why fibrillation is easier to induce at low temperatures, (ii) that there is a minimum size required for fibrillation that depends on temperature, (iii) why the frequency of fibrillation decreases with decreasing temperature, and (iv) that regional cooling may be an anti-arrhythmic therapy for small tissue sizes however it may be pro-arrhythmic for large tissue sizes.
conclusionUsing a mathematical cardiac cell model, we are able to reproduce experimental observations, quantitative experimental results, and discuss possible mechanisms and implications of electrophysiological changes during hypothermia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.