ArticleHeredity2014
Fine-mapping quantitative trait loci affecting murine external ear tissue regeneration in the LG/J by SM/J advanced intercross line.
Article in Heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Digit regeneration is expedited in LG/J healer mice compared to SM/J non-healer mice.NPJ Regenerative medicine · 2025Article
- Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization.Scientific reports · 2024Article
- Allele-specific expression reveals genetic drivers of tissue regeneration in mice.Cell stem cell · 2023Article
- Epithelial-mesenchymal transition: an organizing principle of mammalian regeneration.Frontiers in cell and developmental biology · 2023Article
- Modulating Cellular Responses to Mechanical Forces to Promote Wound Regeneration.Advances in wound care · 2022Review
- Prolyl-hydroxylase inhibitor-induced regeneration of alveolar bone and soft tissue in a mouse model of periodontitis through metabolic reprogramming.Frontiers in dental medicine · 2022Article
- ALPACA: A fast and accurate computer vision approach for automated landmarking of three-dimensional biological structures.Methods in ecology and evolution · 2021Article
- WNT3A-loaded exosomes enable cartilage repair.Journal of extracellular vesicles · 2021Article
- Genetic correlations between cartilage regeneration and degeneration reveal an inverse relationship.Osteoarthritis and cartilage · 2020Article
- RNA-seq analysis of chondrocyte transcriptome reveals genetic heterogeneity in LG/J and SM/J murine strains.Osteoarthritis and cartilage · 2020Article
- Effects of High-Fat Diet and Body Mass on Bone Morphology and Mechanical Properties in 1100 Advanced Intercross Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing.JCI insight · 2019Article
- Using Heterogeneous Stocks for Fine-Mapping Genetically Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2019Review
- Drug delivery and epimorphic salamander-type mouse regeneration: A full parts and labor plan.Advanced drug delivery reviews · 2018Review
- Oxygen, Metabolism, and Regeneration: Lessons from Mice.Trends in molecular medicine · 2017Review
- Enhanced cartilage repair in 'healer' mice-New leads in the search for better clinical options for cartilage repair.Seminars in cell & developmental biology · 2017Review
- Chasing the recipe for a pro-regenerative immune system.Seminars in cell & developmental biology · 2017Review
- Genetic loci that regulate ectopic calcification in response to knee trauma in LG/J by SM/J advanced intercross mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- From Immunity and Vaccines to Mammalian Regeneration.The Journal of infectious diseases · 2015Article
- Drug-induced regeneration in adult mice.Science translational medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
External ear hole closure in LG/J mice represents a model of regenerative response. It is accompanied by the formation of a blastema-like structure and the re-growth of multiple tissues, including cartilage. The ability to regenerate tissue is heritable. An F34 advanced intercross line of mice (Wustl:LG,SM-G34) was generated to identify genomic loci involved in ear hole closure over a 30-day healing period. We mapped 19 quantitative trait loci (QTL) for ear hole closure. Individual gene effects are relatively small (0.08 mm), and most loci have co-dominant effects with phenotypically intermediate heterozygotes. QTL support regions were limited to a median size of 2 Mb containing a median of 19 genes. Positional candidate genes were evaluated using differential transcript expression between LG/J and SM/J healing tissue, function analysis and bioinformatic analysis of single-nucleotide polymorphisms in and around positional candidate genes of interest. Analysis of the set of 34 positional candidate genes and those displaying expression differences revealed over-representation of genes involved in cell cycle regulation/DNA damage, cell migration and adhesion, developmentally related genes and metabolism. This indicates that the healing phenotype in LG/J mice involves multiple physiological mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.