ReviewShock (Augusta, Ga.)2014
Coagulopathy after severe pediatric trauma.
Review in Shock (Augusta, Ga.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Research Priorities for Plasma and Platelet Transfusion Strategies in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2022Pooled it
- Blood Product Transfusion and Coagulopathy in Children with Traumatic Brain Injury: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Indications to perform damage control surgery in pediatric trauma: a scoping review-Are children little adults?World journal of emergency surgery : WJES · 2025Article
- Time-limited association between plasma transfusion and mortality in pediatric traumatic brain injury.The journal of trauma and acute care surgery · 2025Article
- Impact of Early Plasma Resuscitation in Pediatric Severe Traumatic Brain Injury.Journal of pediatric surgery · 2025Article
- Whole blood transfusion in pediatric trauma patients with traumatic brain injury may decrease the risk of early death.Pediatric surgery international · 2025Article
- Non-invasive hemodynamic monitoring and cardiac preload assessment in severely injured children in the emergency department.BMC emergency medicine · 2025Observational
- Testing for bleeding disorders in child abuse: AAP recommendation adherence and testing results.Child abuse & neglect · 2025Article
- Can the BIG score reliably predict outcomes in pediatric traumatic brain ınjury?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Perioperative considerations in the paediatric patient with congenital and acquired coagulopathy.BJA open · 2024Review
- Multiorgan Dysfunction Syndrome in Abusive and Accidental Pediatric Traumatic Brain Injury.Neurocritical care · 2024Article
- Polytrauma in Children—Epidemiology, Acute Diagnostic Evaluation, and Treatment.Deutsches Arzteblatt international · 2024Review
- Optimizing resource utilization: palliative care consultations in critically ill pediatric trauma patients.Trauma surgery & acute care open · 2023Article
- Early coagulopathy after pediatric out-of-hospital cardiac arrest: secondary analysis of a randomized clinical trial.Thrombosis journal · 2022Article
- Plasma thrombin generation kinetics in trauma patients across the age spectrum.Surgery in practice and science · 2022Article
- Rotational thromboelastometry in children presenting to an Australian major trauma centre: A retrospective cohort study.Emergency medicine Australasia : EMA · 2022Observational
- The Influence of Serious Extracranial Injury on In-Hospital Mortality in Children with Severe Traumatic Brain Injury.Journal of personalized medicine · 2022Article
- Fibrinogen Early In Severe paediatric Trauma studY (FEISTY junior): protocol for a randomised controlled trial.BMJ open · 2022Article
- Prophylactic administration of tranexamic acid combined with thromboelastography-guided hemostatic algorithm reduces allogeneic transfusion requirements during pediatric resective epilepsy surgery: A randomized controlled trial.Frontiers in pharmacology · 2022Article
- Predictors of In-Hospital Mortality for Road Traffic Accident-Related Severe Traumatic Brain Injury.Journal of personalized medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Trauma remains the leading cause of morbidity and mortality in the United States among children aged 1 to 21 years. The most common cause of lethality in pediatric trauma is traumatic brain injury. Early coagulopathy has been commonly observed after severe trauma and is usually associated with severe hemorrhage and/or traumatic brain injury. In contrast to adult patients, massive bleeding is less common after pediatric trauma. The classical drivers of trauma-induced coagulopathy include hypothermia, acidosis, hemodilution, and consumption of coagulation factors secondary to local activation of the coagulation system after severe traumatic injury. Furthermore, there is also recent evidence for a distinct mechanism of trauma-induced coagulopathy that involves the activation of the anticoagulant protein C pathway. Whether this new mechanism of posttraumatic coagulopathy plays a role in children is still unknown. The goal of this review is to summarize the current knowledge on the incidence and potential mechanisms of coagulopathy after pediatric trauma and the role of rapid diagnostic tests for early identification of coagulopathy. Finally, we discuss different options for treating coagulopathy after severe pediatric trauma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.