Evidence map›Paper›PMID 24569470›Full record

ArticleBritish journal of cancer2014

Paediatric head CT scan and subsequent risk of malignancy and benign brain tumour: a nation-wide population-based cohort study.

W-Y Huang, C-H Muo, C-Y Lin, Y-M Jen, M-H Yang, J-C Lin, F-C Sung, C-H Kao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 6 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 6 syntheses or guidelines pooled it, 207 citations in OpenAlex.

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  12. Patient-specific organ dose calculation using automatic segmentation and extension of CT scans.Radiation physics and chemistry (Oxford, England : 1993) · 2025
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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

W-Y Huang1] Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan [2] Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
C-H MuoManagement Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan.
C-Y LinDepartment of Radiation Oncology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Y-M JenDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
M-H Yang1] Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan [2] Division of Hematology-Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
J-C LinDepartment of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
F-C Sung1] Management Office for Health Data, China Medical University Hospital, Taichung 404, Taiwan [2] Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
C-H Kao1] Graduate Institute of Clinical Medicine Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan [2] Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
China Medical University · TWTri-Service General Hospital · TWChang Gung Memorial Hospital · TWChina Medical University Hospital · TWNational Defense Medical Center · TWNational Yang Ming University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the possible association between paediatric head computed tomography (CT) examination and increased subsequent risk of malignancy and benign brain tumour.

methodsIn the exposed cohort, 24 418 participants under 18 years of age, who underwent head CT examination between 1998 and 2006, were identified from the Taiwan National Health Insurance Research Database (NHIRD). Patients were followed up until a diagnosis of malignant disease or benign brain tumour, withdrawal from the National Health Insurance (NHI) system, or at the end of 2008.

resultsThe overall risk was not significantly different in the two cohorts (incidence rate=36.72 per 100 000 person-years in the exposed cohort, 28.48 per 100 000 person-years in the unexposed cohort, hazard ratio (HR)=1.29, 95% confidence interval (CI)=0.90-1.85). The risk of benign brain tumour was significantly higher in the exposed cohort than in the unexposed cohort (HR=2.97, 95% CI=1.49-5.93). The frequency of CT examination showed strong correlation with the subsequent overall risk of malignancy and benign brain tumour.

conclusionsWe found that paediatric head CT examination was associated with an increased incidence of benign brain tumour. A large-scale study with longer follow-up is necessary to confirm this result.

Indexed as

AdolescentBrain NeoplasmsChildChild, PreschoolCohort StudiesFemaleHeadHumansIncidenceInfantInfant, NewbornMaleRiskTaiwanTomography, X-Ray Computed

Identifiers

PMID24569470
PMCPMC4007220
OpenAlexW2037505248

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.