ArticleThe Journal of clinical investigation2014
IL-7 receptor blockade following T cell depletion promotes long-term allograft survival.
Article in The Journal of clinical investigation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Stem-like T cells: molecular regulation, functional diversity, and therapeutic implications across diseases.Journal of translational medicine · 2025Review
- Symbiosis with and mimicry of corals were facilitated by immune gene loss and body remodeling in the pygmy seahorse.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Potential drug targets for asthma identified through mendelian randomization analysis.Respiratory research · 2025Article
- Transcriptomic profiling of cytomegalovirus infection in cardiac transplantation: proof-of-concept for a new strategy in tissue markers application.Frontiers in immunology · 2025Article
- Biomarkers from subcutaneous engineered tissues predict acute rejection of organ allografts.Science advances · 2024Article
- Anti-CD4 monoclonal antibody prevents chronic graft-versus-host disease in mice by inducing immune tolerance of CD8Frontiers in immunology · 2024Article
- Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model.Inflammation and regeneration · 2022Article
- Targeting T Follicular Helper Cells to Control Humoral Allogeneic Immunity.Transplantation · 2021Review
- Blockade of IL-7 signaling suppresses inflammatory responses and reverses alopecia areata in C3H/HeJ mice.Science advances · 2021Article
- Acute murine cytomegalovirus disrupts established transplantation tolerance and causes recipient allo-sensitization.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Article
- Integrative analysis of miRNA-mRNA network in high altitude retinopathy by bioinformatics analysis.Bioscience reports · 2021Article
- Approaches for Controlling Antibody-Mediated Allograft Rejection Through Targeting B Cells.Frontiers in immunology · 2021Review
- A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia.Leukemia · 2019Article
- Interleukin-27 promotes CD8+ T cell reconstitution following antibody-mediated lymphoablation.JCI insight · 2019Article
- IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease.The Journal of clinical investigation · 2019Article
- Blocking Formation of the Stable HIV Reservoir: A New Perspective for HIV-1 Cure.Frontiers in immunology · 2019Review
- IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates.Nature communications · 2018Article
- Multipotent Adult Progenitor Cells Suppress T Cell Activation inFrontiers in immunology · 2018Article
- CD147 blockade as a potential and novel treatment of graft rejection.Molecular medicine reports · 2017Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell depletion is commonly used in organ transplantation for immunosuppression; however, a restoration of T cell homeostasis following depletion leads to increased memory T cells, which may promote transplant rejection. The cytokine IL-7 is important for controlling lymphopoiesis under both normal and lymphopenic conditions. Here, we investigated whether blocking IL-7 signaling with a mAb that targets IL-7 receptor α (IL-7Rα) alone or following T cell depletion confers an advantage for allograft survival in murine transplant models. We found that IL-7R blockade alone induced indefinite pancreatic islet allograft survival if anti-IL-7R treatment was started 3 weeks before graft. IL-7R blockade following anti-CD4- and anti-CD8-mediated T cell depletion markedly prolonged skin allograft survival. Furthermore, IL-7 inhibition in combination with T cell depletion synergized with either CTLA-4Ig administration or suboptimal doses of tacrolimus to induce long-term skin graft acceptance in this stringent transplant model. Together, these therapies inhibited T cell reconstitution, decreased memory T cell numbers, increased the relative frequency of Tregs, and abrogated both cellular and humoral alloimmune responses. Our data suggest that IL-7R blockade following T cell depletion has potential as a robust, immunosuppressive therapy in transplantation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.