Trial reportCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
Cigarette smoking, physical activity, and alcohol consumption as predictors of cancer incidence among women at high risk of breast cancer in the NSABP P-1 trial.
Trial report in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- National, regional, and global prevalence of cigarette smoking among women/females in the general population: a systematic review and meta-analysis.Environmental health and preventive medicine · 2021Pooled it
- Does smoking influence the physical activity and lung cancer relation? A systematic review and meta-analysis.European journal of epidemiology · 2016Pooled it
- A systematic review and meta-analysis of physical activity and endometrial cancer risk.European journal of epidemiology · 2015Pooled it
- Symptoms and QOL as Predictors of Chemoprevention Adherence in NRG Oncology/NSABP Trial P-1.Journal of the National Cancer Institute · 2016Trial
- Recent strategies in diagnosis, screening, prevention, and treatment of breast cancer in young women.Discover oncology · 2025Review
- Synergistic strength: unleashing exercise and polyphenols against breast cancer.Cancer cell international · 2025Review
- Human Cytomegalovirus Infection and Breast Cancer: A Literature Review of Clinical and Experimental Data.Biology · 2025Review
- Alcoholic beverage consumption and female breast cancer risk: A systematic review and meta-analysis of prospective cohort studies.Alcohol, clinical & experimental research · 2024Review
- Association between trace elements in cancerous and non-cancerous tissues with the risk of breast cancers in western Iran.Environmental science and pollution research international · 2022Article
- The Global Incidence, Mortality, and Burden of Breast Cancer in 2019: Correlation With Smoking, Drinking, and Drug Use.Frontiers in oncology · 2022Article
- Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC).Breast cancer research : BCR · 2019Article
- Risk of lung cancer and physical activity by smoking status and body mass index, the Norwegian Women and Cancer Study.European journal of epidemiology · 2019Article
- Association Between Physical Activity and Lower Risk of Lung Cancer: A Meta-Analysis of Cohort Studies.Frontiers in oncology · 2019Article
- Identification of microRNAs as potential markers of ovarian toxicity.Journal of applied toxicology : JAT · 2018Article
- Occurrence of Occult Malignancies in Reduction Mammoplasties.Frontiers in surgery · 2018Article
- A case-control study of the association between self-reported occupational and recreational physical activity and lung cancer.Medicine · 2017Article
- Functional analysis of CD14Oncology letters · 2017Article
- Upregulation of HOXA13 as a potential tumorigenesis and progression promoter of LUSC based on qRT-PCR and bioinformatics.International journal of clinical and experimental pathology · 2017Article
- Cigarette Smoking Before and After Breast Cancer Diagnosis: Mortality From Breast Cancer and Smoking-Related Diseases.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Observational
- Ongoing Use of Data and Specimens From National Cancer Institute-Sponsored Cancer Prevention Clinical Trials in the Community Clinical Oncology Program.Seminars in oncology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundNSABP P-1 provides an opportunity to examine the association of behavioral factors with prospectively monitored cancer incidence and interactions with tamoxifen.
methodsFrom 1992 to 1997, 13,388 women with estimated 5-year breast cancer risk greater than 1.66% or a history of lobular carcinoma in situ (87% younger than age 65; 67% postmenopausal) were randomly assigned to tamoxifen versus placebo. Invasive breast cancer, lung cancer, colon cancer, and endometrial cancer were analyzed with Cox regression. Predictors were baseline cigarette smoking, leisure-time physical activity, alcohol consumption, and established risk factors.
resultsAt median 7 years follow-up, we observed 395, 66, 35, and 74 breast cancer, lung cancer, colon cancer, and endometrial cancer, respectively. Women who had smoked were at increased risk of breast cancer (P = 0.007; HR = 1.3 for 15-35 years smoking, HR = 1.6 for ≥ 35 years), lung cancer (P < 0.001; HR = 3.9 for 15-35 years, HR = 18.4 for ≥ 35 years), and colon cancer (P < 0.001; HR = 5.1 for ≥ 35 years) versus never-smokers. Low activity predicted increased breast cancer risk only among women assigned to placebo (P = 0.021 activity main effect, P = 0.013 activity-treatment interaction; HR = 1.4 for the placebo group) and endometrial cancer among all women (P = 0.026, HR = 1.7). Moderate alcohol (>0-1 drink/day) was associated with decreased risk of colon cancer (P = 0.019; HR = 0.35) versus no alcohol. There were no other significant associations between these behaviors and cancer risk.
conclusionAmong women with elevated risk of breast cancer, smoking has an even greater impact on breast cancer risk than observed in past studies in the general population. IMPACT: Women who smoke or are inactive should be informed of the increased risk of multiple types of cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.