Evidence map›Paper›PMID 24569388›Full record

ArticleThe Pediatric infectious disease journal2014

Effectiveness of 2 rotavirus vaccines against rotavirus disease in Taiwanese infants.

Wan-Chi Chang, Catherine Yen, Fang-Tzy Wu, Yhu-Chering Huang, Jen-Shiou Lin, Fu-Chen Huang, Hui-Tzu Yu, Cheng-Liang Chi, Han-Ying Lin, Jacqueline E Tate and 3 more

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In one paragraph

Article in The Pediatric infectious disease journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  17. Use of Patients With Diarrhea Who Test Negative for Rotavirus as Controls to Estimate Rotavirus Vaccine Effectiveness Through Case-Control Studies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wan-Chi ChangFrom the *Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan; †Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA; ‡Department of Health, Research and Diagnostic Center, Centers for Disease Control, Taipei; §Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital at Linkou, and Chang Gung University College of Medicine, Taoyuan; ¶Department of Laboratory Medicine, Changhua Christian Hospital, Changhua; ‖Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung; and **School of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei, Taiwan.
Catherine Yen
Fang-Tzy Wu
Yhu-Chering Huang
Jen-Shiou Lin
Fu-Chen Huang
Hui-Tzu Yu
Cheng-Liang Chi
Han-Ying Lin
Jacqueline E Tate
Umesh D Parashar
Ho-Sheng Wu
Chao A Hsiung

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundTwo rotavirus (RV) vaccines (Rotarix and RotaTeq) are available on the private market in Taiwan, but are not recommended for routine use. We examined RV vaccine effectiveness (VE) against severe RV acute gastroenteritis (AGE) among Taiwanese infants to inform policymakers on the potential benefits of national RV vaccine introduction.

methodsFrom May 2009 to April 2011, a case-control assessment of VE against severe RV AGE was conducted at 3 hospital-based surveillance sites in Taiwan. Case-patients included children aged 8-35 months, hospitalized with laboratory-confirmed RV AGE. Controls included children age-matched within 1 month of age of the case-patient, hospitalized with RV-negative AGE or seen for non-AGE illnesses at the same hospitals. Vaccination history was confirmed through vaccination card or hospital record review. VE was calculated as (1--odds ratio of vaccination) × 100%.

resultsWe enrolled 184 case-patients with RV AGE, 904 RV-negative AGE and 909 non-AGE controls. Two-dose Rotarix series VE against RV gastroenteritis hospitalization was 90.4% [95% confidence interval (CI): 70.3%, 98.1%) and 92.5% (95% CI: 77.1%, 98.5%) with RV-negative AGE and non-AGE controls, respectively. Three-dose RotaTeq series VE was 96.8% (95% CI: 82.3%, 100%) and 97.1% (95% CI: 84%, 100%) with RV-negative AGE and non-AGE controls, respectively.

conclusionsBoth vaccines provided excellent protection against severe RV AGE hospitalization. Addition of RV vaccination into Taiwan's National Immunization Program could substantially decrease AGE hospitalizations among children <3 years. Our findings should help inform policymakers in Taiwan and other similar Asian countries when deciding whether to include RV vaccination into their national immunization programs.

Indexed as

Case-Control StudiesChild, PreschoolFemaleHumansInfantMaleRotavirusRotavirus InfectionsRotavirus VaccinesTaiwanVaccines, AttenuatedRIX4414 vaccineRotaTeqRotavirus VaccinesVaccines, Attenuated

Identifiers

PMID24569388
PMCPMC11980786

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.