Evidence map›Paper›PMID 24569037›Full record

Observational studyJournal of cardiac failure2014

Reduced handgrip strength as a marker of frailty predicts clinical outcomes in patients with heart failure undergoing ventricular assist device placement.

Christine J Chung, Christina Wu, Meaghan Jones, Tomoko S Kato, Tien T Dam, Raymond C Givens, Danielle L Templeton, Mathew S Maurer, Yoshifumi Naka, Hiroo Takayama and 2 more

2 registry-linked trialsAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of cardiac failure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 84 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 9 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03132441 nawithdrawnnot on this mapstarted 2017, after this paper: background citation

A Prospective Trial to Evaluate the Utility of Focused Frailty Interventions on Patients Undergoing Evaluation for Left Ventricular Assist Device (LVAD) Placement

TypeinterventionalSponsorMayo ClinicRan2017 to 2018Enrolled0ConditionsHeart FailureArmsStrength Training for Frailty
NCT03574662 nacompletednot on this mapstarted 2018, after this paper: background citation

A Prospective Trial to Evaluate the Utility of Focused Frailty Interventions on Patients With Advanced Heart Failure

TypeinterventionalSponsorMayo ClinicRan2018 to 2018Enrolled1ConditionsHeart FailureArmsFrailty assessment, Quality of life assessment
3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 9 syntheses or guidelines pooled it, 192 citations in OpenAlex.

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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Christine J ChungDivision of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York. Electronic address: pcs2121@columbia.edu.
Christina WuDivision of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York.
Meaghan JonesDivision of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York.
Tomoko S KatoDivision of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York.
Tien T DamDivision of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York.
Raymond C GivensDivision of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York.
Danielle L TempletonDivision of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York.
Mathew S MaurerDivision of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York.
Yoshifumi NakaDivision of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York.
Hiroo TakayamaDivision of Cardiothoracic Surgery, Department of Surgery, Columbia University Medical Center, New York, New York.
Donna M ManciniDivision of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York.
P Christian SchulzeDivision of Cardiology, Department of Surgery, Columbia University Medical Center, New York, New York.
Columbia University Irving Medical Center · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
POSTDOCTORAL TRAINING IN ARTERIOSCLEROSIS RESEARCHT32HL007343 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HENRY N GINSBERG, Muredach P Reilly · 1985 to 2026
$12.7M
Mechanisms of Fatty Acid Uptake By Cardiac MuscleR01HL073029 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GOLDBERG, IRA J · 2003 to 2021
$6.8M
Cardiac Lipotoxicity and Ceramide Metabolism in Heart FailureR01HL114813 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COLOMBO, PAOLO C, SCHULZE, P. CHRISTIAN · 2013 to 2017
$3.0M
Metabolism in Heart Failure Translational Research CenterP30HL101272 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LANDRY, DONALD W · 2009 to 2010
$1.2M
Cardiac and Skeletal Muscle Metabolism and Proteolysis in Heart FailureK23HL095742 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SCHULZE, P. CHRISTIAN · 2009 to 2013
$677k
Low Magnitude Mechanical Stimulation to Increase Muscle Strength in Frail AdultsK23AG040168 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DAM, THUY-TIEN LE · 2012 to 2015
$643k
NCRR NIH HHS UL1 RR 024156NCRR NIH HHS UL1 RR024156NHLBI NIH HHS HL073029NHLBI NIH HHS K23 HL095742NHLBI NIH HHS K23 HL095742-01NHLBI NIH HHS P30 HL101272NHLBI NIH HHS P30 HL101272-01NHLBI NIH HHS R01 HL073029NHLBI NIH HHS R01 HL114813NHLBI NIH HHS T32 HL007343NIA NIH HHS K23 AG040168
6 · The paper itself

Abstract

backgroundHeart failure (HF) is associated with the derangement of muscle structure and metabolism, contributing to exercise intolerance, frailty, and mortality. Reduced handgrip strength is associated with increased patient frailty and higher morbidity and mortality. We evaluated handgrip strength as a marker of muscle function and frailty for prediction of clinical outcomes after ventricular assist device (VAD) implantation in patients with advanced HF. METHODS AND

resultsHandgrip strength was measured in 72 patients with advanced HF before VAD implantation (2.3 ± 4.9 days pre-VAD). We analyzed dynamics in handgrip strength, laboratory values, postoperative complications, and mortality. Handgrip strength correlated with serum albumin levels (r = 0.334, P = .004). Compared with baseline, handgrip strength increased post-VAD implantation by 18.2 ± 5.6% at 3 months (n = 29) and 45.5 ± 23.9% at 6 months (n = 27). Patients with a handgrip strength <25% of body weight had an increased risk of mortality, increased postoperative complications, and lower survival after VAD implantation.

conclusionPatients with advanced HF show impaired handgrip strength indicating a global myopathy. Handgrip strength <25% of body weight is associated with higher postoperative complication rates and increased mortality after VAD implantation. Thus, the addition of measures of skeletal muscle function underlying the frailty phenotype to traditional risk markers might have incremental prognostic value in patients undergoing evaluation for VAD placement.

Indexed as

Cohort StudiesFemaleHand StrengthHeart-Assist DevicesHeart FailureHumansMaleMiddle AgedPostoperative ComplicationsPredictive Value of TestsSurvival RateTreatment Outcomehandgrip strengthHeart failureskeletal muscleventricular assist device

Identifiers

PMID24569037
PMCPMC4284074
OpenAlexW1977412633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.