ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2014
The relationship between major depression and nonsuicide mortality for U.S. adults: the importance of health behaviors.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Major Depression and Survival in People With Cancer.Psychosomatic medicine · 2021Pooled it
- Prevalent Diagnosed Depression in Relation to Contextual Isolation Among Nursing Home Residents in the United States: A Cross-Sectional Study.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2025Article
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Cigarette Use, Lung Cancer Screening Eligibility and Completion Among Persons With Poor Mental Health.Cancer medicine · 2025Article
- A follow-up study with a double-blinded, randomized controlled vitamin D supplementation trial in patients with major depressive episode (DepFuD): A study protocol and baseline characteristics.Food science & nutrition · 2024Article
- Nonlinear Associations between Physical Function, Physical Activity, Sleep, and Depressive Symptoms in Older Adults.Journal of clinical medicine · 2023Article
- Depressive symptoms and mortality-findings from Helsinki birth cohort study.Acta psychiatrica Scandinavica · 2023Article
- Association of sleep behavior with depression: a cross-sectional study in northwestern China.Frontiers in psychiatry · 2023Article
- The Chinese Inventory of Psychosocial Balance Short-Form Questionnaire for the Older Adults: Validity and Reliability Study.Frontiers in psychology · 2022Article
- Longitudinal trends in the prevalence and treatment of depression among adults with cardiovascular disease: An analysis of national health and nutrition examination survey 2009-2020.Frontiers in psychiatry · 2022Article
- Predicting Ego Integrity Using Prior Ego Development Stages for Older Adults in the Community.International journal of environmental research and public health · 2021Article
- The relationship of frailty and disability with suicidal ideation in late life depression.Aging & mental health · 2021Article
- Insula thickness asymmetry relates to risk of major depressive disorder in middle-aged to older adults.Psychiatry research. Neuroimaging · 2019Article
- Educational Mobility Across Generations and Depressive Symptoms Over 10 Years Among US Latinos.American journal of epidemiology · 2018Article
- Magnitude and sources of distress in mid-life adults with chronic medical illness: an exploratory mixed-methods analysis.Psychology, health & medicine · 2018Article
- Health Lifestyle Behaviors among U.S. Adults.SSM - population health · 2017Article
- Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2017Article
- Depression and Frailty in Late Life: Evidence for a Common Vulnerability.The journals of gerontology. Series B, Psychological sciences and social sciences · 2016Article
- Article
- Predicted Impact of Nicotine Reduction on Smokers with Affective Disorders.Tobacco regulatory science · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesWe aim to elucidate the role of health behaviors and health conditions in the association between depression and mortality. First, we examine the relationship between major depression and nonsuicide mortality among U.S. adults aged 50 and older. Second, we examine the relationship between major depression and cardiovascular disease and cancer, by baseline disease status. Third, we examine the role of health behaviors as potential mediators of the association between major depression and cause-specific mortality.
methodsWe use data from the 1999 National Health Interview Study linked to the 2006 National Death Index (N = 11,369; M age = 65, deaths = 2,162) and Cox proportional hazards models to describe the relationships among major depression, health behaviors (alcohol use, cigarette smoking, physical activity), and nonsuicide mortality. We examine cause-specific mortality (cardiovascular and cancer) by baseline disease status.
resultsMajor depression remains associated with a 43% increase in the risk of death over the follow-up period, after we account for sociodemographic characteristics, health behaviors, and health conditions. Major depression is associated with 2.68 times the risk of cardiovascular disease mortality among those who did not have cardiovascular disease at baseline and 1.82 times for those with baseline cardiovascular disease. Health behaviors reduce the hazard ratio by 17% for all nonsuicide mortality, 3% for cardiovascular disease mortality, and 12% for cancer mortality. DISCUSSION: Our results provide evidence of the important role of health behaviors and health conditions in the depression-mortality relationship and highlight the importance of identifying risk factors for depression among aging adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.