ArticleCell journal2014
Improvement in The Function of Isolated Rat Pancreatic Islets through Reduction of Oxidative Stress Using Traditional Iranian Medicine.
Article in Cell journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies.Frontiers in endocrinology · 2022Pooled it
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- The role of ginseng derivatives against chemotherapy-induced cardiotoxicity: A systematic review of non-clinical studies.Frontiers in cardiovascular medicine · 2023Review
- Ca' Granda,Molecules (Basel, Switzerland) · 2021Article
- RETRACTED: Therapeutic Effects of Gallic Acid in Regulating Senescence and Diabetes; an In Vitro Study.Molecules (Basel, Switzerland) · 2020Article
- Inhibition of LSD1 promotes the differentiation of human induced pluripotent stem cells into insulin-producing cells.Stem cell research & therapy · 2020Article
- Antihyperlipidemic and Antioxidative Properties ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats.Drug design, development and therapy · 2020Article
- Antioxidant Effects of Eugenol on Oxidative Stress Induced by Hydrogen Peroxide in Islets of Langerhans Isolated from Male Mouse.International journal of hepatology · 2020Article
- Thymoquinone attenuates hepatotoxicity and oxidative damage caused by diazinon: anResearch in pharmaceutical sciences · 2018Article
- Treatment of a Woman WithJournal of chiropractic medicine · 2018Article
- Regulation of aging and oxidative stress pathways in aged pancreatic islets using alpha-lipoic acid.Molecular and cellular biochemistry · 2018Article
- Improvement of the functionality of pancreatic Langerhans islets via reduction of bacterial contamination and apoptosis using phenolic compounds.Iranian journal of basic medical sciences · 2018Article
- Protective effect of amlodipine on diazinon-induced changes on oxidative/antioxidant balance in rat hippocampus.Research in pharmaceutical sciences · 2018Article
- Review
- Multiple protective mechanisms of alpha-lipoic acid in oxidation, apoptosis and inflammation against hydrogen peroxide induced toxicity in human lymphocytes.Molecular and cellular biochemistry · 2015Article
- Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review.Journal of traditional and complementary medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePancreatic islets have fewer antioxidant enzymes than other tissues and thus are vulnerable to oxidative stress. In the present study, the effects of nine specifically selected Iranian medical plants on the mitochondria function and survival of isolated rat islets were examined. MATERIALS AND
methodsIn this experimental study, following laparotomy, pancreases of rats were removed and the islets isolated and incubated in vitro for 24 hours. Logarithmic doses of plant materials were added to the islets and incubated for an additional 24 hours after which the viability of the cells and production of reactive oxygen species (ROS) were measured. Levels of insulin production in relation to static and stimulated glucose concen- trations were also determined.
resultsThe tested compounds markedly increased survival of the islet cells, their mi- tochondrial activity, and insulin levels at the same time as reducing production of ROS. Greatest effects were observed in the following order: Peganum harmala, Glycyrrhiza glabra, Satureja hortensis, Rosmarinus officinalis, Teucrium scordium, Aloe vera, Zingiber officinale, Silybum marianum, and Hypericum perforatum at doses of 10, 10(3), 10(4), 10, 10(2), 10(2), 10(-1), 10 and 10(3)μgmL(-1), respectively.
conclusionBased on these results, we suggest that pretreatment with these select- ed Iranian medical plants can improve the outcomes of pancreas transplants and grafts through the control of oxidative stress damage.
Indexed as
Identifiers
24567945PMC4071980W2275164130What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.