Evidence map›Paper›PMID 24567910›Full record

ArticleNeuroImage. Clinical2014

Brain putamen volume changes in newly-diagnosed patients with obstructive sleep apnea.

Rajesh Kumar, Salar Farahvar, Jennifer A Ogren, Paul M Macey, Paul M Thompson, Mary A Woo, Frisca L Yan-Go, Ronald M Harper

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322212 (Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06322212 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2027Enrolled52ConditionsType2diabetesArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rajesh KumarDepartment of Anesthesiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA ; Department of Radiological Sciences, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA ; The Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Salar FarahvarDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Jennifer A OgrenUCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Paul M MaceyUCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095, USA ; The Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Paul M ThompsonDepartment of Neurology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA ; Department of Psychiatry, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Mary A WooUCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Frisca L Yan-GoDepartment of Neurology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Ronald M HarperDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA ; The Brain Research Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA.
University of California, Los Angeles · US

Funding

Brain Axonal Injury in Obstructive Sleep ApneaR01HL113251 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH · 2012 to 2015
$1.4M
NHLBI NIH HHS R01 HL-113251NHLBI NIH HHS R01 HL113251
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is accompanied by cognitive, motor, autonomic, learning, and affective abnormalities. The putamen serves several of these functions, especially motor and autonomic behaviors, but whether global and specific sub-regions of that structure are damaged is unclear. We assessed global and regional putamen volumes in 43 recently-diagnosed, treatment-naïve OSA (age, 46.4 ± 8.8 years; 31 male) and 61 control subjects (47.6 ± 8.8 years; 39 male) using high-resolution T1-weighted images collected with a 3.0-Tesla MRI scanner. Global putamen volumes were calculated, and group differences evaluated with independent samples t-tests, as well as with analysis of covariance (covariates; age, gender, and total intracranial volume). Regional differences between groups were visualized with 3D surface morphometry-based group ratio maps. OSA subjects showed significantly higher global putamen volumes, relative to controls. Regional analyses showed putamen areas with increased and decreased tissue volumes in OSA relative to control subjects, including increases in caudal, mid-dorsal, mid-ventral portions, and ventral regions, while areas with decreased volumes appeared in rostral, mid-dorsal, medial-caudal, and mid-ventral sites. Global putamen volumes were significantly higher in the OSA subjects, but local sites showed both higher and lower volumes. The appearance of localized volume alterations points to differential hypoxic or perfusion action on glia and other tissues within the structure, and may reflect a stage in progression of injury in these newly-diagnosed patients toward the overall volume loss found in patients with chronic OSA. The regional changes may underlie some of the specific deficits in motor, autonomic, and neuropsychologic functions in OSA.

Indexed as

FemaleHumansImage EnhancementImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedPutamenReproducibility of ResultsSensitivity and SpecificitySleep Apnea, Obstructive3D surface morphometry3D, Three dimensionalAHI, Apnea–hypopnea indexAutonomicBAI, Beck Anxiety InventoryBasal gangliaBDI-II, Beck Depression Inventory IICognitionCSF, Cerebrospinal fluidESS, Epworth Sleepiness ScaleFA, Flip angleFOV, Field of viewGRAPPA, Generalized autocalibrating partially parallel acquisitionIntermittent hypoxiaMagnetic resonance imagingMNI, Montreal Neurological InstituteMotorMPRAGE, Magnetization prepared rapid acquisition gradient-echoMRI, Magnetic resonance imagingOSA, Obstructive sleep apneaPD, Proton densityPSQI, Pittsburgh Sleep Quality IndexTE, Echo timeTIV, Total intracranial volumeTR, Repetition time

Identifiers

PMID24567910
PMCPMC3930100
OpenAlexW2038446333

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.