ArticleCommunicative & integrative biology2013
A zinc transporter gene required for development of the nervous system.
Article in Communicative & integrative biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis.Reproductive biology and endocrinology : RB&E · 2022Article
- Stroke subtype-dependent synapse elimination by reactive gliosis in mice.Nature communications · 2021Article
- Review
- Cellular Zinc Homeostasis Contributes to Neuronal Differentiation in Human Induced Pluripotent Stem Cells.Neural plasticity · 2016Article
- A new bioinformatic insight into the associated proteins in psychiatric disorders.SpringerPlus · 2016Article
- Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study.Frontiers in neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The essentiality of zinc for normal brain development is well established. It has been suggested that primary and secondary zinc deficiencies can contribute to the occurrence of numerous human birth defects, including many involving the central nervous system. In a recent study, we searched for zinc transporter genes that were critical for neurodevelopment. We confirmed that ZIP12 is a zinc transporter encoded by the gene slc39a12 that is highly expressed in the central nervous systems of human, mouse, and frog (Xenopus tropicalis).Using loss-of-function methods, we determined that ZIP12 is required for neuronal differentiation and neurite outgrowth and necessary for neurulation and embryonic viability. These results highlight an essential need for zinc regulation during embryogenesis and nervous system development. We suggest that slc39a12 is a candidate gene for inherited neurodevelopmental defects in humans.
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Registered trials
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