Trial reportAnnals of oncology : official journal of the European Society for Medical Oncology2014
The role of body mass index in survival outcome for lymphoma patients: US intergroup experience.
Trial report in Annals of oncology : official journal of the European Society for Medical Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Evaluating the prognostic value of body mass index in diffuse large B-cell lymphoma: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- The impact of actual body weight-based chemotherapy dosing and body size on adverse events and outcome in older patients with breast cancer: Results from Cancer and Leukemia Group B (CALGB) trial 49907 (Alliance A151436).Journal of geriatric oncology · 2018Trial
- The Relationship Between Menopausal Status and Depression in U.S. Women: Insights from the NHANES 2017-March 2020 Cross-Sectional Study.Actas espanolas de psiquiatria · 2025Article
- Body Composition at Diagnosis and Early Response in Pediatric Hodgkin Lymphoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Editorial: Obesity and cancer: the possible molecular links.Frontiers in cell and developmental biology · 2025Article
- The causal effect of adipose tissue on Hodgkin's lymphoma: two-sample Mendelian randomization study and validation.Frontiers in immunology · 2024Article
- The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin's lymphoma-an observational study.Cancer & metabolism · 2023Article
- Body mass index-associated responses to an ABVD-like regimen in newly-diagnosed patients with Hodgkin lymphoma.Frontiers in pharmacology · 2023Article
- Article
- Geriatric assessment in older adults with non-Hodgkin lymphoma: A Young International Society of Geriatric Oncology (YSIOG) review paper.Journal of geriatric oncology · 2022Review
- Prognostic Impact of a Body Mass Index Decrease during First Chemotherapy in Patients with Advanced Follicular Lymphoma.Internal medicine (Tokyo, Japan) · 2022Article
- Body mass index and survival of patients with lymphoma.Leukemia & lymphoma · 2021Article
- Article
- Prognostic Impact of Muscle Quantity and Quality and Fat Distribution in Diffuse Large B-Cell Lymphoma Patients.Frontiers in nutrition · 2021Article
- Clinicopathological characteristics and treatment outcome in obese patients with diffuse large B-cell lymphoma.Translational cancer research · 2020Article
- Prognostic model based on the geriatric nutritional risk index and sarcopenia in patients with diffuse large B-cell lymphoma.BMC cancer · 2020Article
- Influence of body mass index on survival in indolent and mantle cell lymphomas: analysis of the StiL NHL1 trial.Annals of hematology · 2017Article
- Increased body mass index is associated with improved overall survival in extranodal natural killer/T-cell lymphoma, nasal type.Oncotarget · 2017Article
- High Body Mass Index in Elderly Patients With DLBCL Treated With Rituximab-Containing Therapy Compensates for Negative Impact of Male Sex.Journal of the National Comprehensive Cancer Network : JNCCN · 2016Article
- Mechanisms underlying the association between obesity and Hodgkin lymphoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
Corrections and comments
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Authors and funding
13 authors at 12 institutions in 2 countries.
Funding
Abstract
backgroundThe role of body mass index (BMI) in survival outcomes is controversial among lymphoma patients. We evaluated the association between BMI at study entry and failure-free survival (FFS) and overall survival (OS) in three phase III clinical trials, among patients with diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and Hodgkin's lymphoma (HL). PATIENTS AND
methodsA total of 537, 730 and 282 patients with DLBCL, HL and FL were included in the analysis. Baseline patient and clinical characteristics, treatment received and clinical outcomes were compared across BMI categories.
resultsAmong patients with DLBCL, HL and FL, the median age was 70, 33 and 56; 29%, 29% and 37% were obese and 38%, 27% and 37% were overweight, respectively. Age was significantly different among BMI groups in all three studies. Higher BMI groups tended to have more favorable prognosis factors at study entry among DLBCL and HL patients. BMI was not associated with clinical outcome with P-values of 0.89, 0.30 and 0.40 for FFS, and 0.64, 0.67 and 0.09 for OS, for patients with DLBCL, HL and FL, respectively. The association remains non-significant after adjusting for other clinical factors in the Cox model. A subset analysis of males with DLBCL treated on R-CHOP revealed no differences in FFS (P = 0.48) or OS (P = 0.58).
conclusionBMI was not significantly associated with clinical outcomes among patients with DLBCL, HD or FL, in three prospective phase III clinical trials. The findings contradict some previous reports of similar investigations. Further work is required to understand the observed discrepancies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.