ReviewSchizophrenia bulletin2014
Genetic relationships between schizophrenia, bipolar disorder, and schizoaffective disorder.
Review in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
140 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Comorbid Schizophrenia and Psychotic Symptoms in Patients With Bipolar Disorder: A Meta-Analysis of the Global Literature.Bipolar disorders · 2026Pooled it
- Transdiagnostic Neurocognitive Endophenotypes for Schizophrenia, Bipolar I Disorder and a Broad Psychosis/Bipolar I Disorder Phenotype: A Mega-Analysis of Twin and Sibling Data.Schizophrenia bulletin · 2026Pooled it
- Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- A Systematic Review of Studies Reporting Data-Driven Cognitive Subtypes across the Psychosis Spectrum.Neuropsychology review · 2020Pooled it
- Towards a brain-based predictome of mental illness.Human brain mapping · 2020Pooled it
- Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.Molecular neurobiology · 2018Pooled it
- Neurocognition and social cognition as risk markers in adolescents: a comparative study of asymptomatic siblings of Early-Onset Schizophrenia and bipolar disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Computerized adaptive testing of neurocognitive deficits in psychosis.Psychological assessment · 2026Article
- Transdiagnostic alterations of intrinsic brain activity in major psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Polygenic associations with phenotypic classes across the psychosis-affective spectrum.medRxiv : the preprint server for health sciences · 2026Article
- Cognitive pleiotropy reveals disorder-specific and shared biology for schizophrenia and bipolar disorder.medRxiv : the preprint server for health sciences · 2026Article
- Associations between PTSD and psychotic symptoms: A network analysis of patients with psychotic disorders in Uganda: Psychosis-PTSD network analysis.SSM. Mental health · 2026Article
- Emotional and behavioral problems in the offspring of parents with schizophrenia or bipolar disorder: a controlled comparative study.Frontiers in psychiatry · 2026Article
- Understanding Psychotic Depression.Advances in experimental medicine and biology · 2026Review
- Article
- Genomics of schizophrenia, bipolar disorder and major depressive disorder.Nature reviews. Genetics · 2025Review
- Mapping neurophysiological and molecular profiles of heterogeneity and homogeneity in schizophrenia-bipolar disorder.Science advances · 2025Article
- Three Distinct Pathways to First Episode Mania and Psychosis: Latent Class Analysis of Antecedent Psychopathology.Acta psychiatrica Scandinavica · 2025Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
There is substantial evidence for partial overlap of genetic influences on schizophrenia and bipolar disorder, with family, twin, and adoption studies showing a genetic correlation between the disorders of around 0.6. Results of genome-wide association studies are consistent with commonly occurring genetic risk variants, contributing to both the shared and nonshared aspects, while studies of large, rare chromosomal structural variants, particularly copy number variants, show a stronger influence on schizophrenia than bipolar disorder to date. Schizoaffective disorder has been less investigated but shows substantial familial overlap with both schizophrenia and bipolar disorder. A twin analysis is consistent with genetic influences on schizoaffective episodes being entirely shared with genetic influences on schizophrenic and manic episodes, while association studies suggest the possibility of some relatively specific genetic influences on broadly defined schizoaffective disorder, bipolar subtype. Further insights into genetic relationships between these disorders are expected as studies continue to increase in sample size and in technical and analytical sophistication, information on phenotypes beyond clinical diagnoses are increasingly incorporated, and approaches such as next-generation sequencing identify additional types of genetic risk variant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.