ArticleProceedings of the National Academy of Sciences of the United States of America2014
Trends in structural coverage of the protein universe and the impact of the Protein Structure Initiative.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.
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36 citing papers in PubMed.
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- Optimal selection of suitable templates in protein interface prediction.Bioinformatics (Oxford, England) · 2023Article
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- Decomposing compounds enables reconstruction of interaction fingerprints for structure-based drug screening.Journal of cheminformatics · 2022Article
- Residue-based pharmacophore approaches to study protein-protein interactions.Current opinion in structural biology · 2021Review
- NMR Structure Determinations of Small Proteins Using only One Fractionally 20%Molecules (Basel, Switzerland) · 2021Article
- Computational methods and tools for binding site recognition between proteins and small molecules: from classical geometrical approaches to modern machine learning strategies.Journal of computer-aided molecular design · 2019Article
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- Unique function words characterize genomic proteins.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Validation of LDLr Activity as a Tool to Improve Genetic Diagnosis of Familial Hypercholesterolemia: A Retrospective on Functional Characterization of LDLr Variants.International journal of molecular sciences · 2018Review
- Integrated Structural Biology for α-Helical Membrane Protein Structure Determination.Structure (London, England : 1993) · 2018Article
- fDETECT webserver: fast predictor of propensity for protein production, purification, and crystallization.BMC bioinformatics · 2018Article
- Homology modeling in a dynamical world.Protein science : a publication of the Protein Society · 2017Article
- Enhanced unbiased sampling of protein dynamics using evolutionary coupling information.Scientific reports · 2017Article
- Development of a motif-based topology-independent structure comparison method to identify evolutionarily related folds.Proteins · 2016Article
- NMR in structural genomics to increase structural coverage of the protein universe: Delivered by Prof. Kurt Wüthrich on 7 July 2013 at the 38th FEBS Congress in St. Petersburg, Russia.The FEBS journal · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
The exponential growth of protein sequence data provides an ever-expanding body of unannotated and misannotated proteins. The National Institutes of Health-supported Protein Structure Initiative and related worldwide structural genomics efforts facilitate functional annotation of proteins through structural characterization. Recently there have been profound changes in the taxonomic composition of sequence databases, which are effectively redefining the scope and contribution of these large-scale structure-based efforts. The faster-growing bacterial genomic entries have overtaken the eukaryotic entries over the last 5 y, but also have become more redundant. Despite the enormous increase in the number of sequences, the overall structural coverage of proteins--including proteins for which reliable homology models can be generated--on the residue level has increased from 30% to 40% over the last 10 y. Structural genomics efforts contributed ∼50% of this new structural coverage, despite determining only ∼10% of all new structures. Based on current trends, it is expected that ∼55% structural coverage (the level required for significant functional insight) will be achieved within 15 y, whereas without structural genomics efforts, realizing this goal will take approximately twice as long.
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