ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2014
Mortality associated with seasonal and pandemic influenza and respiratory syncytial virus among children <5 years of age in a high HIV prevalence setting--South Africa, 1998-2009.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 4 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Pooled it
- B-Cell Immunophenotyping to Predict Vaccination Outcome in the Immunocompromised - A Systematic Review.Frontiers in immunology · 2021Pooled it
- Heterogeneity in Estimates of the Impact of Influenza on Population Mortality: A Systematic Review.American journal of epidemiology · 2018Pooled it
- Pooled it
- Influenza vaccination of pregnant women protects them over two consecutive influenza seasons in a randomized controlled trial.Expert review of vaccines · 2016Trial
- Estimates of the national burden of respiratory syncytial virus in Kenyan children aged under 5 years, 2010-2018.BMC medicine · 2023Article
- Observational
- The dangers of performative scientism as the alternative to anti-scientific policymaking: A critical, preliminary assessment of South Africa's Covid-19 response and its consequences.World development · 2021Article
- Highly dampened blood transcriptome response in HIV patients after influenza infection.Scientific reports · 2021Article
- Article
- Burden of respiratory viral infection in persons with human immunodeficiency virus.Influenza and other respiratory viruses · 2020Observational
- Influenza disease burden among potential target risk groups for immunization in South Africa, 2013-2015.Vaccine · 2020Article
- Burden of influenza-associated respiratory and circulatory mortality in India, 2010-2013.Journal of global health · 2020Article
- Etiology, clinical, and epidemiological characteristics of severe respiratory infection in people living with HIV.International journal of STD & AIDS · 2020Observational
- Article
- Health and economic burden of influenza-associated illness in South Africa, 2013-2015.Influenza and other respiratory viruses · 2019Article
- Quantifying How Different Clinical Presentations, Levels of Severity, and Healthcare Attendance Shape the Burden of Influenza-associated Illness: A Modeling Study From South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- The Fraction of Rhinovirus Detections Attributable to Mild and Severe Respiratory Illness in a Setting of High Human Immunodeficiency Virus Prevalence, South Africa, 2013-2015.The Journal of infectious diseases · 2019Article
- Burden and epidemiology of influenza- and respiratory syncytial virus-associated severe acute respiratory illness hospitalization in Madagascar, 2011-2016.Influenza and other respiratory viruses · 2019Article
- The Impact of Influenza and Tuberculosis Interaction on Mortality Among Individuals Aged ≥15 Years Hospitalized With Severe Respiratory Illness in South Africa, 2010-2016.Open forum infectious diseases · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThere are few published data describing the mortality burden associated with influenza and respiratory syncytial virus (RSV) infection in children in low- and middle-income countries and particularly from Africa and settings with high prevalence of human immunodeficiency virus (HIV).
methodsWe modeled the excess mortality attributable to influenza (seasonal and pandemic) and RSV infection by applying Poisson regression models to monthly all-respiratory and pneumonia and influenza deaths, using national influenza and RSV laboratory surveillance data as covariates. In addition, we estimated the seasonal influenza- and RSV-associated deaths among HIV-infected and -uninfected children using Poisson regression models that incorporated HIV prevalence and highly active antiretroviral therapy coverage as covariates.
resultsIn children <5 years of age, the mean annual numbers of seasonal influenza- and RSV-associated all-respiratory deaths were 452 (8 per 100 000 person-years [PY]) and 546 (10 per 100 000 PY), respectively. Infants <1 year of age experienced higher mortality rates compared with children 1-4 years of age for both influenza (22 vs 5 per 100 000 PY) and RSV (35 vs 4 per 100 000 PY). HIV-infected compared with HIV-uninfected children <5 years of age were at increased risk of death associated with influenza (age-adjusted relative risk [aRR], 11.5; 95% confidence interval [CI], 9.6-12.6) and RSV (aRR, 8.1; 95% CI, 6.9-9.3) infection. In 2009, we estimated 549 (11 per 100 000 PY) all-respiratory influenza A(H1N1)pdm09-associated deaths among children aged <5 years.
conclusionsOur findings support increased research efforts to guide and prioritize interventions such as influenza vaccination and HIV prevention in low- and middle-income countries with high HIV prevalence such as South Africa.
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