ArticleClinical rheumatology2014
Mean platelet volume as an indicator of disease activity in juvenile SLE.
Article in Clinical rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Meta-analysis of peripheral mean platelet volume in patients with mental disorders: Comparisons in depression, anxiety, bipolar disorder, and schizophrenia.Brain and behavior · 2023Pooled it
- Lack of association between mean platelet volume and disease activity in systemic lupus erythematosus patients: a systematic review and meta-analysis.Rheumatology international · 2018Pooled it
- Red blood cell distribution width-to-platelet ratio as a disease activity-associated factor in systemic lupus erythematosus.Medicine · 2018Trial
- The causal relationship between platelet indices and liver cancer: a bidirectional two-sample Mendelian randomization study.Discover oncology · 2025Article
- Association between Mean Platelet Volume and Systemic Lupus Erythematosus: A Meta-Analysis.Iranian journal of public health · 2024Review
- Monocyte-to-high-density lipoprotein ratio and systemic immune-inflammation index: Potential parameters for the evaluation of disease activity and severity in Graves' ophthalmopathy?International ophthalmology · 2024Article
- Assessment of hematologic indices for diagnosis in juvenile systemic lupus erythematosus.Reumatologia · 2024Article
- Effect of thyroid hormone status on complete blood cell count-derived inflammatory biomarkers in patients with moderate-to-severe Graves' ophthalmopathy.International ophthalmology · 2023Article
- Contraction Band Necrosis with Dephosphorylated Connexin 43 in Rat Myocardium after Daily Cocaine Administration.International journal of molecular sciences · 2022Article
- Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?Clinical medicine insights. Arthritis and musculoskeletal disorders · 2022Article
- Mean platelet volume can indicate dietary adherence and disease severity of celiac disease.Northern clinics of Istanbul · 2022Article
- A cross-sectional study on evaluation of complete blood count-associated parameters for the diagnosis of acute appendicitis.Health science reports · 2021Article
- Elevated mean platelet volume in oral lichen planus and increased blood urea nitrogen level in its red-form: an observational study.BMC oral health · 2021Observational
- Low Intra-Individual Variation in Mean Platelet Volume Over Time in Systemic Lupus Erythematosus.Frontiers in medicine · 2021Article
- Analysis of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and mean platelet volume to platelet count ratio in children with acute stage of immunoglobulin A vasculitis and assessment of their suitability for predicting the course of the disease.Rheumatology international · 2019Article
- Misunderstandings Between Platelets and Neutrophils Build in Chronic Inflammation.Frontiers in immunology · 2019Review
- Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions.Mediators of inflammation · 2019Review
- Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus.The open rheumatology journal · 2018Article
- Platelet distribution width as a novel indicator of disease activity in systemic lupus erythematosus.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Article
- New Insights on Platelets and Platelet-Derived Microparticles in Systemic Lupus Erythematosus.Current rheumatology reports · 2017Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to assess mean platelet volume (MPV) in children with systemic lupus erythematosus (SLE) at the active and inactive stages. Twenty children with SLE and 30 age- and gender-matched controls were enrolled. Demographic data, SLE disease activity index (SLEDAI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), MPV, complement 3 (C3), complement 4 (C4), urine protein (Up), and urine creatinine (Ucr) values upon reactivation and remission phases were recorded. MPV was statistically higher in patients than in controls and significantly increased in active phase compared to inactive phase (p = 0.001). A MPV level of 8.4 fL was determined as predictive cutoff value of activation of SLE (sensitivity 75 %, specificity 90 %). MPV was positively correlated with SLEDAI (p = 0.01, r = 0.55), ESR (p = 0.01, r = 0.45), CRP (p = 0.04, r = 0.24), and Up/Ucr (p = 0.01, r = 0.45) and negatively correlated with C3 (p = 0.02, r = -0.36), albumin (p = 0.01, r = -0.63), and Hb (p = 0.01, r = -0.48). There was not any significant association between MPV and the histological classification of lupus nephritis (p = 0.65). MPV might be used as an early indicator of reactivation in children with SLE. MPV seemed to be more accurate than ESR, CRP, and C3 for monitoring the disease activity in SLE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.