ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2014
Investigating the role of transferrin in the distribution of iron, manganese, copper, and zinc.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Role of zinc in health and disease.Clinical and experimental medicine · 2024Review
- Structures and coordination chemistry of transporters involved in manganese and iron homeostasis.Biochemical Society transactions · 2023Review
- Speciation analysis of manganese against the background of its different content in the blood serum of dairy cows.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Article
- Article
- The Potential Roles of Blood-Brain Barrier and Blood-Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis.Nutrients · 2021Review
- Manganese-free chow, a refined non-invasive solution to reduce gastrointestinal signal for TLaboratory animals · 2020Article
- Trace Elements, PPARs, and Metabolic Syndrome.International journal of molecular sciences · 2020Review
- The Combined Effects of Cr(III) Supplementation and Iron Deficiency on the Copper and Zinc Status in Wistar Rats.Biological trace element research · 2019Article
- Crosstalk between zinc and free fatty acids in plasma.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019Review
- Article
- Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure.Data in brief · 2017Article
- Influence of iron metabolism on manganese transport and toxicity.Metallomics : integrated biometal science · 2017Review
- A SLC39A8 variant causes manganese deficiency, and glycosylation and mitochondrial disorders.Journal of inherited metabolic disease · 2017Article
- Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure.Data in brief · 2016Article
- SLC39A8 Deficiency: A Disorder of Manganese Transport and Glycosylation.American journal of human genetics · 2015Article
- Iron incorporation into MnSOD A (bacterial Mn-dependent superoxide dismutase) leads to the formation of a peroxidase/catalase implicated in oxidative damage to bacteria.Biochimica et biophysica acta · 2015Article
- Pharmacokinetic evaluation of the equivalency of gavage, dietary, and drinking water exposure to manganese in F344 rats.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Impact of low- and high-molecular-mass components of human serum on NAMI-A binding to transferrin.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2015Article
- The use of hypotransferrinemic mice in studies of iron biology.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2015Review
- Variance components of short-term biomarkers of manganese exposure in an inception cohort of welding trainees.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The essential role of transferrin in mammalian iron metabolism is firmly established. Integral to our understanding of transferrin, studies in hypotransferrinemic mice, a model of inherited transferrin deficiency, have demonstrated that transferrin is essential for iron delivery for erythropoiesis and in the regulation of expression of hepcidin, a hormone that inhibits macrophage and enterocyte iron efflux. Here we investigate a potential role for transferrin in the distribution of three other physiologic metals, manganese, copper, and zinc. We first assessed metal content in transferrin-rich fractions of wild-type mouse sera and demonstrate that although both iron and manganese cofractionated predominantly with transferrin, the absolute levels of manganese are several orders of magnitude lower than those of iron. We next measured metal content in multiple tissues in wild-type and hypotransferrinemic mice of various ages. Tissue metal imbalances were severe for iron and minimal to moderate for some metals in some tissues in hypotransferrinemic mice. Metal levels measured in a transferrin-replete yet hepcidin-deficient and iron-loaded mouse strain suggested that the observed imbalances in tissue copper, zinc, and manganese levels were not all specific to hypotransferrinemic mice or caused directly by transferrin deficiency. Overall, our results suggest that transferrin does not have a primary role in the distribution of manganese, copper, or zinc to tissues and that the abnormalities observed in tissue manganese levels are not attributable to a direct role for transferrin in manganese metabolism but rather are attributable to an indirect effect of transferrin deficiency on hepcidin expression and/or iron metabolism.
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