ReviewNature reviews. Rheumatology2014
Pain and the context.
Review in Nature reviews. Rheumatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Placebo and nocebo effects and mechanisms associated with pharmacological interventions: an umbrella review.BMJ open · 2023Pooled it
- The Nocebo Effect: A Review of Contemporary Experimental Research.International journal of behavioral medicine · 2022Pooled it
- Red induces hyperalgesia and white induces hypoalgesia regardless of pain modality.Scientific reports · 2023Trial
- Matching actual treatment with patient administration-route-preference improves analgesic response among acute low back pain patients-a randomized prospective trial.Journal of orthopaedic surgery and research · 2020Trial
- Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications.Experimental physiology · 2026Review
- Article
- Placebo Effect on Pain-Related Autonomic Responses in a State of Experimentally-Induced Sensitization.European journal of pain (London, England) · 2026Observational
- Women's real-time pain and stress during medical abortion: An ecological momentary assessment study.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Wobble board instability enhances proactive postural control.Chaos, solitons, and fractals · 2025Article
- Article
- A surprise induced by a visual-haptic illusion in virtual reality can lead to motor improvement.Scientific reports · 2025Article
- The association between test anxiety, learning strategies, and open-label placebo effects on academic test performance: a secondary analysis of a randomized controlled trial.Frontiers in psychology · 2025Article
- Placebo and nocebo effect in pain.Handbook of clinical neurology · 2025Review
- Spatiotemporal integration of contextual and sensory information within the cortical hierarchy in human pain experience.PLoS biology · 2024Article
- Modulatory Processes in Craniofacial Pain States.Advances in neurobiology · 2024Article
- The Biology of Placebo and Nocebo Effects on Experimental and Chronic Pain: State of the Art.Journal of clinical medicine · 2023Review
- Complexity theory in the management of patients with musculoskeletal painBiomedica : revista del Instituto Nacional de Salud · 2022Article
- Understanding Contextual Factors Effects and Their Implications for Italian Physiotherapists: Findings from a National Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2021Article
- Review
- Touch and social support influence interpersonal synchrony and pain.Social cognitive and affective neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is a sensory and emotional experience that is substantially modulated by psychological, social and contextual factors. Research now indicates that the influence of these factors is even more powerful than expected and involves the therapeutic response to analgesic drugs as well as the pain experience itself, which in some circumstances can even be a form of reward. Different experimental approaches and models, both in the laboratory and in the clinical setting, have been used to better characterize and understand the complex neurobiology of pain modulation. These approaches include placebo analgesia, nocebo hyperalgesia, hidden administration of analgesics, and the manipulation of the pain-reward relationship. Overall, these studies show that different neurochemical systems are activated in different positive and negative contexts. Moreover, pain can activate reward mechanisms when experienced within contexts that have special positive meaning. Because routine medical practice usually takes place in contexts that use different rituals, these neurobiological insights might have profound clinical implications.
Indexed as
Identifiers
24567065What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.