ReviewNature reviews. Immunology2014
Intestinal epithelial cells: regulators of barrier function and immune homeostasis.
Review in Nature reviews. Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03617640 (The Enteric Nervous System as Modulator of Mucosal Immune Cells), which is not on this map. Cited by 1,670 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Enteric Nervous System as Modulator of Mucosal Immune Cells
Who cites it
1,670 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prenatal Maternal Stress and Infant Gut Microbiome in Human and Animal Studies: A Comprehensive Systematic Review.Developmental psychobiology · 2026Pooled it
- The role of natural products in the intestinal barrier: a bibliometric analysis from 2004 to 2025.Frontiers in immunology · 2026Pooled it
- Moxibustion and the gut microbiota-inflammation axis: a systematic review and meta-analysis of clinical and preclinical studies.Frontiers in cellular and infection microbiology · 2026Pooled it
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
- Circadian synchronization between diet and gut microbiota in modulating host's health.Gut microbes · 2026Review
- Mongolian warm acupuncture improves colonic barrier function and immune responses via the TLR4/MyD88/NF-κB pathway in insomnia rats.IBRO neuroscience reports · 2026Article
- Bridging environmental pollution and immune dysregulation: How microplastics disrupt gut homeostasis to promote allergic diseases.Virulence · 2026Review
- 5-FU chemotherapy induces functional CD7Science China. Life sciences · 2026Article
- Microbial cues and T cell immunity: deciphering their interactions in chronic liver disease.Experimental & molecular medicine · 2026Review
- Microbiome-Derived Tryptophan Metabolites Regulate AhR Signaling to Restore Epithelial Barrier Integrity in Inflammatory Bowel Disease.MicrobiologyOpen · 2026Review
- Viral-Gut Microbiota Interactions: Implications for the Gut Mucosa in Inflammatory Bowel Disease.International journal of molecular sciences · 2026Review
- Protective effects of selenium-modified Viola philippica polysaccharide-loaded yeast microcapsules against Salmonella Typhimurium infection in chicks.Poultry science · 2026Article
- Review
- Novel insights intomSystems · 2026Article
- Review
- TLR2 Regulates α-Synuclein Phosphorylation and Release in an Enteroendocrine Cell Model.Molecular neurobiology · 2026Article
- Microbiome-Derived Metabolic Signaling in the Gut-Skin Axis: Implications for Nutricosmetics and Healthy Skin Aging.Nutrients · 2026Review
- Climate Change-Mediated Temperature Extremes: Effects on the Immune System and Associations with Immune-Related Diseases.Clinical reviews in allergy & immunology · 2026Review
- Gut Microbiota as a Molecular Regulator of Mineral Homeostasis in Horses: Mechanisms and Future Perspectives.International journal of molecular sciences · 2026Review
- Combination Effects ofBiology · 2026Article
1,610 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The abundance of innate and adaptive immune cells that reside together with trillions of beneficial commensal microorganisms in the mammalian gastrointestinal tract requires barrier and regulatory mechanisms that conserve host-microbial interactions and tissue homeostasis. This homeostasis depends on the diverse functions of intestinal epithelial cells (IECs), which include the physical segregation of commensal bacteria and the integration of microbial signals. Hence, IECs are crucial mediators of intestinal homeostasis that enable the establishment of an immunological environment permissive to colonization by commensal bacteria. In this Review, we provide a comprehensive overview of how IECs maintain host-commensal microbial relationships and immune cell homeostasis in the intestine.
Indexed as
Identifiers
24566914What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.