ArticleInflammation2014
Overexpression of Fas and FasL is associated with infectious complications and severity of experimental severe acute pancreatitis by promoting apoptosis of lymphocytes.
Article in Inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Kujiol A Inhibits Interferon-γ and Interleukin-2 Expression and the NFATc2 Interaction with Their Promoters in T Cells.Molecules (Basel, Switzerland) · 2026Article
- Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026Review
- Diagnosis of infected pancreatic necrosis: A review of the role of blood biomarkers.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Review
- Ubiquitin-specific protease 7 regulates macrophage polarization via pyruvate kinase M2-mediated metabolic reprogramming in severe acute pancreatitis.Cell death & disease · 2025Article
- Kujigamberol Inhibits IFN-γ and IL-2 mRNA Expression and NFATc2 Binding to Their Promoters in Response to a Phorbol Ester and Ionomycin Stimulation.Molecules (Basel, Switzerland) · 2025Article
- Review
- Apoptotic cell death in disease-Current understanding of the NCCD 2023.Cell death and differentiation · 2023Review
- An Improved Time- and Labor- Efficient Protocol for Mouse Primary Hepatocyte Isolation.Journal of visualized experiments : JoVE · 2021Article
- Complete hemogram: simple and cost-effective in staging and predicting outcome in acute pancreatitis.Wiener klinische Wochenschrift · 2021Article
- Systemic Immune-Inflammation Index for Predicting the Prognosis of Critically Ill Patients with Acute Pancreatitis.International journal of general medicine · 2021Article
- Deciphering the molecular pathways of apoptosis using purified fractions from leaf extract of Basella alba through studying the regulation of apoptosis related genes.Molecular biology reports · 2021Article
- T Lymphocytes: A Promising Immunotherapeutic Target for Pancreatitis and Pancreatic Cancer?Frontiers in oncology · 2020Review
- Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis.Frontiers in cellular and infection microbiology · 2020Review
- Glycyrrhizic acid modulates the atrazine-induced apoptosis in rabbit spleen.Environmental science and pollution research international · 2019Article
- Immunomodulatory effect ofExperimental and therapeutic medicine · 2018Article
- Association between KIF1B (rs17401966) polymorphism and hepatocellular carcinoma susceptibility: a meta-analysis.OncoTargets and therapy · 2018Article
- Endothelial protein C receptor polymorphisms and risk of sepsis in a Chinese population.The Journal of international medical research · 2017Article
- Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-Mediators of inflammation · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the relationship of Fas and Fas ligand (FasL) expression and apoptosis of lymphocytes in relation to the pathogenic immune response and infectious complications observed in experimental severe acute pancreatitis in mice. Forty male Balb/c mice were randomly divided into control, mild (MAP), and severe acute pancreatitis (SAP) groups. Overexpression of Fas/FasL messenger ribonucleic acid (mRNA) and protein was observed in spleen-derived lymphocytes in SAP (p < 0.01). Apoptosis of these resulted in a depletion of circulating lymphocytes in this group (p < 0.05). A further significant change in the SAP group with infectious complications was observed. A positive relationship was found between the Fas/FasL expression and lymphocyte apoptosis, and negative relationships were observed between Fas/FasL expression and CD4(+) and CD19(+) lymphocytes and the CD4(+)/CD8(+) ratio in SAP mice (p < 0.01). The results suggest that the overexpression of Fas/FasL is associated with infectious complications and severity of experimental severe acute pancreatitis by promoting apoptosis of lymphocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.