Evidence map›Paper›PMID 24566855›Full record

SynthesisInternational journal of obesity (2005)2015

Epigenetics and human obesity.

S J van Dijk, P L Molloy, H Varinli, J L Morrison, B S Muhlhausler, Members of EpiSCOPE

2 registry-linked trialsAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 154 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
154citing papers in PubMed, 4 pooled it
20.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03165812 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Single Anastomosis Duodeno Jejunal Bypass With Sleeve Gastrectomy (SADJB-SG) Versus Intensive Medical Therapy (IMT) in the Treatment of Type 2 Diabetes Mellitus Among Asian Patients With BMI 23.5 - 30 kg/m2: A Clinical Trial

TypeinterventionalSponsorUniversiti Putra MalaysiaRan2017 to 2019Enrolled84ConditionsDiabetes Mellitus, Type 2, OverweightArmsSADJB-SG group, IMT group
NCT06080425 nacompletednot on this mapstarted 2023, after this paper: background citation

Addressing Intergenerational Obesity and Promoting Healthy Eating and Physical Activity Among Individuals [PIHRK'D] Living With Diabetes in Rural Kentucky

TypeinterventionalSponsorThe University of Texas Medical Branch, GalvestonRan2023 to 2026Enrolled48ConditionsDiabetes Mellitus, Type 2ArmsMedical Nutrition Therapy
3 · Its place in the literature

Who cites it

154 citing papers in PubMed, 4 syntheses or guidelines pooled it, 347 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019
    Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Observational
  13. Review
  14. Epigenetics of Childhood Obesity.Hormone research in paediatrics · 2026
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review

94 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

S J van DijkCSIRO Animal, Food and Health Sciences, Preventative Health Flagship, North Ryde, New South Wales, Australia.
P L MolloyCSIRO Animal, Food and Health Sciences, Preventative Health Flagship, North Ryde, New South Wales, Australia.
H Varinli1] CSIRO Animal, Food and Health Sciences, Preventative Health Flagship, North Ryde, New South Wales, Australia [2] Department of Biological Sciences, Macquarie University, North Ryde, New South Wales, Australia [3] Cancer Research Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
J L MorrisonEarly Origins of Adult Health Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia.
B S Muhlhausler1] FOODplus Research Centre, School of Agriculture Food and Wine, Waite Campus, The University of Adelaide, Adelaide, South Australia, Australia [2] Women's and Children's Health Research Institute, Adelaide, South Australia, Australia.
Members of EpiSCOPE
Commonwealth Scientific and Industrial Research Organisation · AUWomen's & Children's Health Research Institute · AUThe University of Adelaide · AUUniversity of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent technological advances in epigenome profiling have led to an increasing number of studies investigating the role of the epigenome in obesity. There is also evidence that environmental exposures during early life can induce persistent alterations in the epigenome, which may lead to an increased risk of obesity later in life.

methodThis paper provides a systematic review of studies investigating the association between obesity and either global, site-specific or genome-wide methylation of DNA. Studies on the impact of pre- and postnatal interventions on methylation and obesity are also reviewed. We discuss outstanding questions, and introduce EpiSCOPE, a multidisciplinary research program aimed at increasing the understanding of epigenetic changes in emergence of obesity.

resultsAn electronic search for relevant articles, published between September 2008 and September 2013 was performed. From the 319 articles identified, 46 studies were included and reviewed. The studies provided no consistent evidence for a relationship between global methylation and obesity. The studies did identify multiple obesity-associated differentially methylated sites, mainly in blood cells. Extensive, but small, alterations in methylation at specific sites were observed in weight loss intervention studies, and several associations between methylation marks at birth and later life obesity were found.

conclusionsOverall, significant progress has been made in the field of epigenetics and obesity and the first potential epigenetic markers for obesity that could be detected at birth have been identified. Eventually this may help in predicting an individual's obesity risk at a young age and opens possibilities for introducing targeted prevention strategies. It has also become clear that several epigenetic marks are modifiable, by changing the exposure in utero, but also by lifestyle changes in adult life, which implies that there is the potential for interventions to be introduced in postnatal life to modify unfavourable epigenomic profiles.

Indexed as

EpigenomicsGlobal HealthWeight LossCardiovascular DiseasesCross-Sectional StudiesDiabetes Mellitus, Type 2DNA MethylationEnvironmental ExposureHumansLife StyleLongitudinal StudiesObesity

Identifiers

PMID24566855
OpenAlexW2062336804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.