Evidence map›Paper›PMID 24566817›Full record

GuidelineNature reviews. Endocrinology2014

Expert consensus document: A consensus on the medical treatment of acromegaly.

Andrea Giustina, Philippe Chanson, David Kleinberg, Marcello D Bronstein, David R Clemmons, Anne Klibanski, Aart J van der Lely, Christian J Strasburger, Steven W Lamberts, Ken K Y Ho and 3 more

Registry-linked trialAbstract readGuidelineReviewConsensus Statement
PubMed Publisher
In one paragraph

Guideline in Nature reviews. Endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03439709 (Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma From an Endocrinological Point of View), which is not on this map. Cited by 157 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
157citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03439709 phase3unknown statusnot on this mapstarted 2018, after this paper: background citation

Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma From an Endocrinological Point of View (MERGE Study): a Randomized, Phase 3 Trial

TypeinterventionalSponsorSamsung Medical CenterRan2018 to 2022Enrolled90ConditionsAcromegaly Due to Pituitary AdenomaArmsGamma knife radiosurgery, Lanreotide 60Mg Solution for Injection
3 · Its place in the literature

Who cites it

157 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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97 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andrea GiustinaChair of Endocrinology, University of Brescia, via Biseo 17, 25100 Brescia, Italy.
Philippe ChansonAssistance Publique-Hôpitaux de Paris, Service d'Endocrinologie et des Maladies de la Reproduction, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Paris, F 94275, France.
David KleinbergNeuroendocrine Unit, New York University School of Medicine, Department of Veterans Affairs Medical Centre, 423 East 23rd Street, Room 16043W, New York, NY 10010, USA.
Marcello D BronsteinNeuroendocrine Unit, Division of Endocrinology and Metabolism, University of São Paulo Medical School, Avenue Dr. Eneas de Carvalho, 255, 7° Andar, Sala 7037, São Paulo, CEP 05403 000, Brazil.
David R ClemmonsDepartment of Medicine, University of North Carolina, CB# 7170, 8024 Burnett-Womack, Chapel Hill, NC 27599, USA.
Anne KlibanskiNeuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Aart J van der LelyDepartment of Internal Medicine, Division of Endocrinology, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, Netherlands.
Christian J StrasburgerDepartment of Endocrinology, Charite Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany.
Steven W LambertsDepartment of Internal Medicine, Division of Endocrinology, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, Netherlands.
Ken K Y HoPrincess Alexandra Hospital, 199 Ipswich Road, Brisbane, QLD 4102, Australia.
Felipe F CasanuevaSantiago de Compostela University and CIBERobn, Santiago de Compostela, E-15780, Spain.
Shlomo MelmedDepartment of Medicine, Cedars-Sinai Medical Center, Room 2015, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Acromegaly Consensus Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In March 2013, the Acromegaly Consensus Group met to revise and update guidelines for the medical treatment of acromegaly. The meeting comprised experts skilled in the medical management of acromegaly. The group considered treatment goals covering biochemical, clinical and tumour volume outcomes, and the place in guidelines of somatostatin receptor ligands, growth hormone receptor antagonists and dopamine agonists, and alternative modalities for treatment including combination therapy and novel treatments. This document represents the conclusions of the workshop consensus.

Indexed as

AcromegalyConsensusHuman Growth HormoneHumansInsulin-Like Growth Factor IPituitary NeoplasmsTreatment OutcomeHuman Growth HormoneInsulin-Like Growth Factor I

Identifiers

PMID24566817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.