ReviewEuropean journal of nutrition2014
Exploring the benefits and challenges of establishing a DRI-like process for bioactives.
Review in European journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Flavan-3-ols and Cardiometabolic Health: First Ever Dietary Bioactive Guideline.Advances in nutrition (Bethesda, Md.) · 2022Guideline
- Dietary guidance for lutein: consideration for intake recommendations is scientifically supported.European journal of nutrition · 2017Pooled it
- Trial
- Adhering to dietary guidelines does not yield flavanol intake levels associated with beneficial cardiovascular effects.Food & function · 2026Article
- Plant Foods as Healthy Sources of Dietary Fibre, Microbiota Modulation and Bioactive Compounds: Beyond Definitions-A Review.Nutrients · 2026Review
- A Framework for Developing Intake and Use Guidance for Dietary Supplement Bioactives.Advances in nutrition (Bethesda, Md.) · 2026Review
- Multifaceted role of plant polyphenols in human health: a comprehensive review.Food science and biotechnology · 2026Review
- Nutrition's role in extending healthspan: CRN-international symposium report.European journal of nutrition · 2026Article
- Relationship between dietary flavan-3-ols intake and mortality in metabolic syndrome population; a large cohort study.Frontiers in nutrition · 2025Article
- Review
- Advancing nutrition science to meet evolving global health needs.European journal of nutrition · 2023Article
- Foundational Nutrition: Implications for Human Health.Nutrients · 2023Review
- Potential roles of dietary zeaxanthin and lutein in macular health and function.Nutrition reviews · 2023Review
- Have safety and efficacy assessments of bioactives come of age?Molecular aspects of medicine · 2023Review
- Women's health: optimal nutrition throughout the lifecycle.European journal of nutrition · 2022Article
- ( -)-Epicatechin and cardiometabolic risk factors: a focus on potential mechanisms of action.Pflugers Archiv : European journal of physiology · 2022Review
- Science-based policy: targeted nutrition for all ages and the role of bioactives.European journal of nutrition · 2021Article
- Growing Evidence of a Proven Mechanism Shows Vitamin K2 Can Impact Health Conditions Beyond Bone and Cardiovascular.Integrative medicine (Encinitas, Calif.) · 2021Article
- Polyphenols and Visual Health: Potential Effects on Degenerative Retinal Diseases.Molecules (Basel, Switzerland) · 2021Review
- Linking biomarkers of oxidative stress and disease with flavonoid consumption: From experimental models to humans.Redox biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bioactives can be defined as: "Constituents in foods or dietary supplements, other than those needed to meet basic human nutritional needs, which are responsible for changes in health status" (Office of Disease Prevention and Health Promotion, Office of Public Health and Science, Department of Health and Human Services in Fed Reg 69:55821-55822, 2004). Although traditional nutrients, such as vitamins, minerals, protein, essential fatty acids and essential amino acids, have dietary reference intake (DRI) values, there is no such evaluative process for bioactives. For certain classes of bioactives, substantial scientific evidence exists to validate a relationship between their intake and enhanced health conditions or reduced risk of disease. In addition, the study of bioactives and their relationship to disease risk is a growing area of research supported by government, academic institutions, and food and supplement manufacturers. Importantly, consumers are purchasing foods containing bioactives, yet there is no evaluative process in place to let the public know how strong the science is behind the benefits or the quantitative amounts needed to achieve these beneficial health effects. This conference, Bioactives: Qualitative Nutrient Reference Values for Life-stage Groups?, explored why it is important to have a DRI-like process for bioactives and challenges for establishing such a process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.