ArticleInfection and immunity2014
Attenuation of intestinal inflammation in interleukin-10-deficient mice infected with Citrobacter rodentium.
Article in Infection and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Citrobacter rodentium infection activates colonic lamina propria group 2 innate lymphoid cells.PLoS pathogens · 2025Article
- Inflammation-Induced Th17 Cells Synergize with the Inflammation-Trained Microbiota to Mediate Host Resiliency Against Intestinal Injury.Inflammatory bowel diseases · 2025Article
- An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases.Frontiers in immunology · 2024Review
- Loss of Interleukin-10 (IL-10) Signaling Promotes IL-22-Dependent Host Defenses against Acute Clostridioides difficile Infection.Infection and immunity · 2021Article
- Dietary patterns, food groups and nutrients in Crohn's disease: associations with gut and systemic inflammation.Scientific reports · 2021Article
- Immunomodulation and Intestinal Morpho-Functional Aspects of a Novel Gram-Negative BacteriumFrontiers in microbiology · 2021Article
- Targeting IL-27 and/or IL-10 in Experimental Murine Visceral Leishmaniasis.The American journal of tropical medicine and hygiene · 2020Article
- IL-21 Promotes Intestinal Memory IgA Responses.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Indoles from the commensal microbiota act via the AHR and IL-10 to tune the cellular composition of the colonic epithelium during aging.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Prevention of enteric bacterial infections and modulation of gut microbiota with conjugated linoleic acids producingGut microbes · 2020Article
- Tipping the balance: inhibitory checkpoints in intestinal homeostasis.Mucosal immunology · 2019Review
- Induction of PIR-A/BJournal of gastroenterology · 2018Article
- Can We Target Endogenous Anti-inflammatory Responses as a Therapeutic Strategy for Inflammatory Bowel Disease?Inflammatory bowel diseases · 2018Review
- Article
- S100A4 contributes to colitis development by increasing the adherence of Citrobacter rodentium in intestinal epithelial cells.Scientific reports · 2017Article
- Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature.Inflammatory bowel diseases · 2016Review
- Citrobacter rodentium-induced colitis: A robust model to study mucosal immune responses in the gut.Journal of immunological methods · 2015Article
- IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis.Nature communications · 2015Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Interleukin-10 (IL-10) curtails immune responses to microbial infection and autoantigens and contributes to intestinal immune homeostasis, yet administration of IL-10 has not been effective at attenuating chronic intestinal inflammatory conditions, suggesting that its immune functions may be context dependent. To gain a broader understanding of the importance of IL-10 in controlling mucosal immune responses to infectious challenges, we employed the murine attaching and effacing pathogen Citrobacter rodentium, which colonizes primarily the surfaces of the cecum and colon and causes transient mucosal inflammation driven by Th17 and Th1 T helper cells. Infection induced macrophage and dendritic cell production of IL-10, which diminished antibacterial host defenses, because IL-10-deficient mice cleared infection faster than wild-type controls. In parallel, the mice had less acute infection-associated colitis and resolved it more rapidly than controls. Importantly, transient C. rodentium infection protected IL-10-deficient mice against the later development of spontaneous colitis that normally occurs with aging in these mice. Genome-wide expression studies revealed that IL-10 deficiency was associated with downregulation of proinflammatory pathways but increased expression of the anti-inflammatory cytokine IL-27 in response to infection. IL-27 was found to suppress in vitro Th17 and, to a lesser degree, Th1 differentiation independent of IL-10. Furthermore, neutralization of IL-27 resulted in more severe colitis in infected IL-10-deficient mice. Together, these findings indicate that IL-10 is dispensable for resolving C. rodentium-associated colitis and further suggest that IL-27 may be a critical factor for controlling intestinal inflammation and Th17 and Th1 development by IL-10-independent mechanisms.
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Registered trials
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