ArticleNeurotoxicology and teratology
Prenatal methamphetamine exposure and neurodevelopmental outcomes in children from 1 to 3 years.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Prenatal Methamphetamine Exposure: Effects on Child Development–A Systematic Review.Deutsches Arzteblatt international · 2021Pooled it
- Favorable outcome in a neonate with methamphetamine, tobacco, and alcohol exposure with Hypoxic Ischemic Encephalopathy managed using therapeutic hypothermia.Toxicology reports · 2026Article
- Peabody Developmental Motor Scales-Second Edition: A Reliable Tool for Assessing Motor Development in Children.Journal of clinical medicine · 2025Review
- A Perinatal Review of Prevalence and Risk Factors for Substance Abuse Among Pregnant Women in Singapore.Cureus · 2025Article
- Impact of healthy pregnancy and lifestyle in mothers on developmental delay in their offspring: a strength-based analysis of a longitudinal study among indigenous children in Australia.BMC pregnancy and childbirth · 2024Article
- Maternal use of methamphetamine alters cardiovascular function in the adult offspring.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2023Review
- The tragedy of smoking, alcohol, and multiple substance use during pregnancy.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2022Article
- Methamphetamine: burden, mechanism and impact on pregnancy, the fetus, and newborn.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- An environmental scan of impacts and interventions for women with methamphetamine use in pregnancy and their children.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021Review
- The Adverse Effects of Prenatal METH Exposure on the Offspring: A Review.Frontiers in pharmacology · 2021Review
- A Validated Method for the Simultaneous Determination of Methamphetamine and 3,4-Methylenedioxy-International journal of analytical chemistry · 2020Article
- The epigenetic legacy of illicit drugs: developmental exposures and late-life phenotypes.Environmental epigenetics · 2019Review
- Article
- Detrimental effects of self-administered methamphetamine during pregnancy on offspring development in the rat.Drug and alcohol dependence · 2017Article
- Global motion perception is related to motor function in 4.5-year-old children born at risk of abnormal development.Vision research · 2017Article
- Effects of Neonatal Methamphetamine and Stress on Brain Monoamines and Corticosterone in Preweanling Rats.Neurotoxicity research · 2017Article
- Prenatal exposure to recreational drugs affects global motion perception in preschool children.Scientific reports · 2015Article
- Global motion perception is independent from contrast sensitivity for coherent motion direction discrimination and visual acuity in 4.5-year-old children.Vision research · 2015Article
- Prenatal methamphetamine exposure is associated with reduced subcortical volumes in neonates.Neurotoxicology and teratologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundDespite the evidence that women world-wide are using methamphetamine (MA) during pregnancy little is known about the neurodevelopment of their children.
designThe controlled, prospective longitudinal New Zealand (NZ) Infant Development, Environment and Lifestyle (IDEAL) study was carried out in Auckland, NZ. Participants were 103 children exposed to MA prenatally and 107 who were not exposed. The Mental Developmental Index (MDI) and the Psychomotor Developmental Index (PDI) of the Bayley Scales of Infant Development, Second Edition (BSID-II) measured cognitive and motor performances at ages 1, 2 and 3, and the Peabody Developmental Motor Scale, Second Edition (PDMS-II) measured gross and fine motor performances at 1 and 3. Measures of the child's environment included the Home Observation of Measurement of the Environment and the Maternal Lifestyle Interview. The Substance Use Inventory measured maternal drug use.
resultsAfter controlling for other drug use and contextual factors, prenatal MA exposure was associated with poorer motor performance at 1 and 2 years on the BSID-II. No differences were observed for cognitive development (MDI). Relative to non-MA exposed children, longitudinal scores on the PDI and the gross motor scale of the PDMS-2 were 4.3 and 3.2 points lower, respectively. Being male and of Maori descent predicted lower cognitive scores (MDI) and being male predicted lower fine motor scores (PDMS-2).
conclusionsPrenatal exposure to MA was associated with delayed gross motor development over the first 3 years, but not with cognitive development. However, being male and of Maori descent were both associated with poorer cognitive outcomes. Males in general did more poorly on tasks related to fine motor development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.