ReviewAging2014
Evolution of sexually dimorphic longevity in humans.
Review in Aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES.Epigenetics · 2025Article
- Epigenetic Clock Analysis of Sex Chromosome Aneuploidies.Aging cell · 2025Article
- Biological constraint, evolutionary spandrels and antagonistic pleiotropy.Ageing research reviews · 2024Review
- Prepubertal castration eliminates sex differences in lifespan and growth trajectories in genetically heterogeneous mice.Aging cell · 2023Article
- Mortality and morbidity in ageing men: Biology, Lifestyle and Environment.Reviews in endocrine & metabolic disorders · 2022Review
- Sirtuins are Not Conserved Longevity Genes.Life metabolism · 2022Article
- Article
- A chromosome-level genome of Antechinus flavipes provides a reference for an Australian marsupial genus with male death after mating.Molecular ecology resources · 2022Article
- In Experimental Dilated Cardiomyopathy Heart Failure and Survival Are Adversely Affected by a Lack of Sexual Interactions.International journal of molecular sciences · 2020Article
- Androgens' effects on cerebrovascular function in health and disease.Biology of sex differences · 2020Review
- Sex gap in aging and longevity: can sex chromosomes play a role?Biology of sex differences · 2018Review
- Sex-specific regulation of aging in Caenorhabditis elegans.Aging cell · 2018Article
- Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog').Free radical biology & medicine · 2018Article
- Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains.Archives of biochemistry and biophysics · 2017Article
- Sex Differences in Age-Related Decline of Urinary Insulin-Like Growth Factor-Binding Protein-3 Levels in Adult Bonobos and Chimpanzees.Frontiers in endocrinology · 2016Article
- Trajectories and phenotypes with estrogen exposures across the lifespan: What does Goldilocks have to do with it?Hormones and behavior · 2015Article
- Life History Strategies of Male Criminal Offenders: Verifying Traditional Life History Patterns.Evolutionary psychology : an international journal of evolutionary approaches to psychology and behaviorArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Why do humans live longer than other higher primates? Why do women live longer than men? What is the significance of the menopause? Answers to these questions may be sought by reference to the mechanisms by which human aging might have evolved. Here, an evolutionary hypothesis is presented that could answer all three questions, based on the following suppositions. First, that the evolution of increased human longevity was driven by increased late-life reproduction by men in polygynous primordial societies. Second, that the lack of a corresponding increase in female reproductive lifespan reflects evolutionary constraint on late-life oocyte production. Third, that antagonistic pleiotropy acting on androgen-generated secondary sexual characteristics in men increased reproductive success earlier in life, but shortened lifespan. That the gender gap in aging is attributable to androgens appears more likely given a recent report of exceptional longevity in eunuchs. Yet androgen depletion therapy, now used to treat prostatic hyperplasia, appears to accelerate other aspects of aging (e.g. cardiovascular disease). One possibility is that low levels of androgens throughout life reduces aging rate, but late-life androgen depletion does not.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.