ArticleRespiratory physiology & neurobiology2014
Learning to breathe: habituation of Hering-Breuer inflation reflex emerges with postnatal brainstem maturation.
Article in Respiratory physiology & neurobiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Anaesthesia for diagnostic and therapeutic bronchoscopy.BJA education · 2026Review
- Article
- Peritoneal sepsis caused by Escherichia coli triggers brainstem inflammation and alters the function of sympatho-respiratory control circuits.Journal of neuroinflammation · 2024Article
- Neurobiology of Coughing in Children.Journal of clinical medicine · 2023Review
- Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans.Journal of neural engineering · 2023Article
- Rates of ultrasonic vocalizations are more strongly related than acoustic features to non-vocal behaviors in mouse pups.Frontiers in behavioral neuroscience · 2022Article
- Protective ventilation from ICU to operating room: state of art and new horizons.Korean journal of anesthesiology · 2020Review
- P2X3 receptor antagonism reduces the occurrence of apnoeas in newborn rats.Respiratory physiology & neurobiology · 2020Article
- Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis.The Journal of pharmacology and experimental therapeutics · 2019Review
- Hypothesis: Pulmonary Afferent Activity Patterns During Slow, Deep Breathing Contribute to the Neural Induction of Physiological Relaxation.Frontiers in physiology · 2019Article
- Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats.Brain, behavior, and immunity · 2018Article
- Calibration of thresholds for functional engagement of vagal A, B and C fiber groupsBioelectronics in medicine · 2018Article
- Embryonic hindbrain patterning genes delineate distinct cardio-respiratory and metabolic homeostatic populations in the adult.Scientific reports · 2017Article
- Kölliker-Fuse nuclei regulate respiratory rhythm variability via a gain-control mechanism.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Vagal Afferent Innervation of the Airways in Health and Disease.Physiological reviews · 2016Review
- Article
- Increased cardio-respiratory coupling evoked by slow deep breathing can persist in normal humans.Respiratory physiology & neurobiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The Hering-Breuer (HBR) reflex is considered a major regulatory feedback for the generation and patterning of respiratory activity. While HBR is important in neonates, its significance in adults is controversial. Previous experiments that investigated the plasticity of entrainment of the respiratory rhythm by vagal input demonstrated postnatal changes in HBR plasticity. Here we analyzed postnatal changes in the plasticity of HBR by mimicking the classic lung inflation tests with repetitive tonic vagal stimulation across different postnatal stages in an in situ perfused brainstem preparation of rat. The study shows that neonates stereotypically exhibit HBR stimulus-dependent prolongation of expiration while juvenile preparations (>postnatal day 16) showed significant habituation of HBR following repetitive stimulation. Subsequent experiments employing physiological lung inflation tests in situ confirmed HBR habituation in juveniles. We conclude that postnatal emergence of HBR habituation explains the weak contribution and high activation threshold of HBR in the regulation of eupnea.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.