ArticleMolecules (Basel, Switzerland)2014
Triptolide induces s phase arrest and apoptosis in gallbladder cancer cells.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Apoptosis- and ferroptosis-inducing activity of triptolide in SBC-3 human small-cell lung cancer cells.Journal of natural medicines · 2026Article
- The Therapeutic Effects of Bioactive Compounds on Colorectal Cancer via PI3K/Akt/mTOR Signaling Pathway: A Critical Review.Food science & nutrition · 2024Review
- Antitumor mechanisms and future clinical applications of the natural product triptolide.Cancer cell international · 2024Review
- Triptolide inhibits epithelial ovarian tumor growth by blocking the hedgehog/Gli pathway.Aging · 2023Article
- Evaluation of Anticancer and Anti-Inflammatory Activities of Some Synthetic Rearranged Abietanes.International journal of molecular sciences · 2023Article
- Recent Updates on the Functional Impact of Kahweol and Cafestol on Cancer.Molecules (Basel, Switzerland) · 2022Review
- Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer.Journal of Cancer · 2020Article
- Effects of puerarin on the pharmacokinetics of triptolide in rats.Pharmaceutical biology · 2019Article
- Compatibility with Panax notoginseng and Rehmannia glutinosa Alleviates the Hepatotoxicity and Nephrotoxicity of Tripterygium wilfordii via Modulating the Pharmacokinetics of Triptolide.International journal of molecular sciences · 2018Article
- Schisandrin B inhibits cell proliferation and induces apoptosis in human cholangiocarcinoma cells.Oncology reports · 2016Article
- The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.Journal of experimental & clinical cancer research : CR · 2016Article
- Synergistic antitumor activity of gemcitabine combined with triptolide in pancreatic cancer cells.Oncology letters · 2016Article
- Knockdown of SALL4 inhibits the proliferation and reverses the resistance of MCF-7/ADR cells to doxorubicin hydrochloride.BMC molecular biology · 2016Article
- Gall bladder carcinoma: Aggressive malignancy with protean loco-regional and distant spread.World journal of clinical cases · 2015Review
- Antiproliferative and apoptosis-inducing activity of schisandrin B against human glioma cells.Cancer cell international · 2015Article
- 20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway.Drug design, development and therapy · 2015Article
- Targets and molecular mechanisms of triptolide in cancer therapy.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2014Review
- Immunosuppressive, anti-inflammatory and anti-cancer properties of triptolide: A mini review.Avicenna journal of phytomedicineReview
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gallbladder carcinoma is the most common malignancy of the biliary tract, with a very low 5-year survival rate and extremely poor prognosis. Thus, new effective treatments and drugs are urgently needed for the treatment of this malignancy. In this study, for the first time we investigated the effects of triptolide on gallbladder cancer cells and identified the mechanisms underlying its potential anticancer effects. The MTT assay showed that triptolide decreased cell viability in a dose- and time-dependent manner. The results of the colony formation assay indicated that triptolide strongly suppressed colony formation ability in GBC-SD and SGC-996 cells. Flow cytometric analysis revealed that triptolide induced S phase arrest in gallbladder cancer cells. In addition, triptolide induced apoptosis, as shown by the results of annexin V/propidium iodide double-staining and Hoechst 33342 staining. Furthermore, triptolide decreased mitochondrial membrane potential (ΔΨm) in a dose-dependent manner. Finally, western blot analysis of triptolide-treated cells revealed the activation of caspase-3, caspase-9, PARP, and Bcl-2; this result demonstrated that triptolide induced apoptosis in gallbladder cancer cells by regulating apoptosis-related protein expression, and suggests that triptolide may be a promising drug to treat gallbladder carcinoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.