ArticleAntimicrobial agents and chemotherapy2014
N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Experimental Evolution of Drug Resistance for Antibiotic Target Discovery in Chlamydia trachomatis.Methods in molecular biology (Clifton, N.J.) · 2027Article
- A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia.PLoS biology · 2025Article
- A 2-pyridone amide inhibitor of transcriptional activity inAntimicrobial agents and chemotherapy · 2023Article
- Design, Biological Evaluation, and Computer-Aided Analysis of Dihydrothiazepines as Selective Antichlamydial Agents.Journal of medicinal chemistry · 2023Article
- Synthesis of novel sulphamethoxazole derivatives and exploration of their anticancer and antimicrobial properties.PloS one · 2023Article
- Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors.ACS omega · 2022Article
- Modified Fluoroquinolones as Antimicrobial Compounds TargetingInternational journal of molecular sciences · 2022Article
- Inhibitory Activity of Pyrroloisoxazolidine Derivatives againstBioMed research international · 2021Article
- Synthesis and Antichlamydial Activity of Molecules Based on Dysregulators of Cylindrical Proteases.Journal of medicinal chemistry · 2020Article
- Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone basedMedChemComm · 2019Article
- A High-throughput, High-content, Liquid-based C. elegans Pathosystem.Journal of visualized experiments : JoVE · 2018Article
- Red FluorescentFrontiers in microbiology · 2018Article
- Evaluating the Antibiotic Susceptibility ofFrontiers in microbiology · 2018Article
- N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF.Antimicrobial agents and chemotherapy · 2017Article
- Dibenzocyclooctadiene lignans from Schisandra spp. selectively inhibit the growth of the intracellular bacteria Chlamydia pneumoniae and Chlamydia trachomatis.The Journal of antibiotics · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distinct from that of sulfonamide antibiotics, as para-aminobenzoic acid did not reduce efficacy. Chemical inhibitors play an important role in Chlamydia research as probes of potential targets and as drug development starting points.
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