Evidence map›Paper›PMID 24565973›Full record

ArticleCellular immunology

T cell interleukin-15 surface expression in chimpanzees infected with human immunodeficiency virus.

Annette R Rodriguez, Vida Hodara, Kruthi Murthy, LaShayla Morrow, Melissa Sanchez, Amy E Bienvenu, Krishna K Murthy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Detection of Signal Regulatory Protein α inFrontiers in immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Annette R RodriguezResearch Centers at Minority Institutions, Biophotonics Core, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, United States; Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78245, United States. Electronic address: Annette.Rodriguez@utsa.edu.
Vida HodaraDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78245, United States.
Kruthi MurthyDepartment of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, United States.
LaShayla MorrowDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78245, United States.
Melissa SanchezDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78245, United States.
Amy E BienvenuDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78245, United States.
Krishna K MurthyDepartment of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, TX 78245, United States.
Texas Biomedical Research Institute · USThe University of Texas Health Science Center at San Antonio · USThe University of Texas at San Antonio · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
RCMI Center for Interdiscplinary Health Research CIHRG12MD007591 · NIMHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI PERRY, GEORGE · 2012 to 2016
$10.4M
MAINTENANCE OF CHIMPANZEES FOR HEPATITIS/AIDS RESEARCHN01HB027091 · HB · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI MURTHY, KRISHNA K · 1992 to 2000
$290k
NHLBI NIH HHS N01 HB027091NHLBI NIH HHS N01-HB-27091NIH HHS P51 OD011133NIMHD NIH HHS G12 MD007591NIMHD NIH HHS G12MD007591
6 · The paper itself

Abstract

Interleukin-15 (IL-15) contributes to natural killer cell development and immune regulation. However, IL-15 and interferon-gamma (IFN-γ) production are significantly reduced during progression to AIDS. We have previously reported that HIV infected chimpanzees (Pan troglodytes) express CD3-CD8+ IFN-γ+ natural killer (NK) cells with an inverse correlation to plasma HIV viral load. To expand on our initial study, we examined a larger population of HIV infected chimpanzees (n=10). Whole blood flow cytometry analyses showed that recombinant gp120 (rgp120) or recombinant IL-15 induces specific CD3-CD8+ IFN-γ+ NK cells at higher levels than CD3+CD8+ IFN-γ+ T cells in HIV infected specimens. Interestingly, peripheral blood T cells exhibited 0.5-3% IL-15 surface Tcell/NKT cell phenotypes, and rIL-15 stimulation significantly (P<0.007) up-regulated CD4+CD25+ T cell expression. Importantly, these data demonstrate novel T cell interleukin-15 expression and indicate a plausible regulatory mechanism for this cell-type during viral infection.

Indexed as

AnimalsCD3 ComplexCD4 AntigensCD8 AntigensGene ExpressionHIV-1HIV Envelope Protein gp120HIV InfectionsHumansImmunophenotypingInterferon-gammaInterleukin-15Interleukin-2 Receptor alpha SubunitKiller Cells, NaturalPan troglodytesRecombinant ProteinsCD3 ComplexCD4 AntigensCD8 AntigensHIV Envelope Protein gp120Interferon-gammaInterleukin-15Interleukin-2 Receptor alpha SubunitRecombinant ProteinsAIDSHIVInterferon-gammaInterleukin-15Natural killer cellNKT cellTumor necrosis factor-alpha

Identifiers

PMID24565973
PMCPMC4373471
OpenAlexW1994033075

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.