Evidence map›Paper›PMID 24565797›Full record

ArticleBiochimica et biophysica acta2014

Branched amphiphilic peptide capsules: cellular uptake and retention of encapsulated solutes.

Pinakin Sukthankar, L Adriana Avila, Susan K Whitaker, Takeo Iwamoto, Alfred Morgenstern, Christos Apostolidis, Ke Liu, Robert P Hanzlik, Ekaterina Dadachova, John M Tomich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Organization and Structure of Branched Amphipathic Oligopeptide Bilayers.Langmuir : the ACS journal of surfaces and colloids · 2016
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pinakin SukthankarDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66502, USA.
L Adriana AvilaDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66502, USA.
Susan K WhitakerDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66502, USA.
Takeo IwamotoDivision of Biochemistry, Core Research Facilities, Jikei University School of Medicine, Tokyo 105-8461, Japan.
Alfred MorgensternEuropean Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, D-76125 Karlsruhe, Germany.
Christos ApostolidisEuropean Commission, Joint Research Centre, Institute for Transuranium Elements, P.O. Box 2340, D-76125 Karlsruhe, Germany.
Ke LiuDepartment of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045-7582, USA.
Robert P HanzlikDepartment of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045-7582, USA.
Ekaterina DadachovaDepartment of Radiology, Albert Einstein College of Medicine, 1695A Eastchester Rd., Bronx, NY 10461, USA.
John M TomichDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66502, USA. Electronic address: jtomich@ksu.edu.

Funding

ROLE OF EPOXIDES IN METABOLISM AND DRUG TOXICITYR01GM021784 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HANZLIK, ROBERT P · 1985 to 2012
$2.9M
MODEL SYNTHETIC CHANNEL ASSEMBLIESR01GM074096 · NIGMS · KANSAS STATE UNIVERSITY · PI TOMICH, JOHN M · 2005 to 2013
$2.3M
NIGMS NIH HHS R01 GM021784NIGMS NIH HHS R01 GM074096
6 · The paper itself

Abstract

Branched amphiphilic peptide capsules (BAPCs) are peptide nano-spheres comprised of equimolar proportions of two branched peptide sequences bis(FLIVI)-K-KKKK and bis(FLIVIGSII)-K-KKKK that self-assemble to form bilayer delimited capsules. In two recent publications we described the lipid analogous characteristics of our BAPCs, examined their initial assembly, mode of fusion, solute encapsulation, and resizing and delineated their capability to be maintained at a specific size by storing them at 4°C. In this report we describe the stability, size limitations of encapsulation, cellular localization, retention and, bio-distribution of the BAPCs in vivo. The ability of our constructs to retain alpha particle emitting radionuclides without any apparent leakage and their persistence in the peri-nuclear region of the cell for extended periods of time, coupled with their ease of preparation and potential tune-ability, makes them attractive as biocompatible carriers for targeted cancer therapy using particle emitting radioisotopes. This article is part of a Special Issue entitled: Interfacially Active Peptides and Proteins. Guest Editors: William C. Wimley and Kalina Hristova.

Indexed as

ActiniumCapsulesDrug Delivery SystemsHumansLipid BilayersLiposomesNanospheresNeoplasmsParticle SizePeptidesRadioisotopesSolutionsActiniumCapsulesLipid BilayersLiposomesPeptidesRadioisotopesSolutions(225)ActiniumAlpha particle therapyBAPCNano-capsulePeptide capsuleSelf-assembling peptide

Identifiers

PMID24565797
PMCPMC4082727

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.