ArticleThe Journal of steroid biochemistry and molecular biology2014
Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells.
Article in The Journal of steroid biochemistry and molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- 1,25-dihydroxyvitamin D3 improves non-alcoholic steatohepatitis phenotype in a diet-induced rat model.Frontiers in endocrinology · 2025Article
- Immunoceuticals: Harnessing Their Immunomodulatory Potential to Promote Health and Wellness.Nutrients · 2022Review
- Codelivery of 1α,25-Dihydroxyvitamin DMolecular pharmaceutics · 2022Article
- The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility.Endocrine connections · 2021Review
- A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression.The Journal of steroid biochemistry and molecular biology · 2020Article
- Significance of LL-37 on Immunomodulation and Disease Outcome.BioMed research international · 2020Review
- Antimicrobial and Immune-Modulatory Effects of Vitamin D Provide Promising Antibiotics-Independent Approaches to Tackle Bacterial Infections - Lessons Learnt from a Literature Survey.European journal of microbiology & immunology · 2019Review
- 1,25(OH)Gut pathogens · 2019Article
- The endogenous antimicrobial cathelicidin LL37 induces platelet activation and augments thrombus formation.Blood advances · 2018Article
- Dietary modulation of endogenous host defense peptide synthesis as an alternative approach to in-feed antibiotics.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2018Review
- 1α,25-dihydroxyvitamin DNanomedicine (London, England) · 2018Article
- Parameters of the Immune System and Vitamin D Levels in Old Individuals.Frontiers in immunology · 2018Article
- Vitamin A and D in allergy: from experimental animal models and cellular studies to human disease.Allergo journal international · 2018Review
- Colonic transcriptional response to 1α,25(OH)The Journal of steroid biochemistry and molecular biology · 2017Article
- Review
- Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Review
- Vitamin D sufficiency and Staphylococcus aureus infection in children.The Pediatric infectious disease journal · 2015Article
- Regulation of calcitriol biosynthesis and activity: focus on gestational vitamin D deficiency and adverse pregnancy outcomes.Nutrients · 2015Review
- Local effects of adipose tissue in psoriasis and psoriatic arthritis.Psoriasis (Auckland, N.Z.)Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Production of the human cathelicidin antimicrobial peptide gene (hCAP18/LL-37), is regulated by 1α,25-dihydroxyvitamin D3 (1,25D3) and is critical in the killing of pathogens by innate immune cells. In addition, secreted LL-37 binds extracellular receptors and modulates the recruitment and activity of both innate and adaptive immune cells. Evidence suggests that during infections activated immune cells locally produce increased levels of 1,25D3 thus increasing production of hCAP18/LL-37. The relative expression levels of hCAP18/LL-37 among different immune cell types are not well characterized. The aim of this study was to determine the relative levels of hCAP18/LL-37 in human peripheral blood immune cells and determine to what extent 1,25D3 increased its expression in peripheral blood-derived cells. We show for the first time, a hierarchy of expression of hCAP18 in freshly isolated cells with low levels in lymphocytes, intermediate levels in monocytes and the highest levels found in neutrophils. In peripheral blood-derived cells, the highest levels of hCAP18 following treatment with 1,25D3 were in macrophages, while comparatively lower levels were found in GM-CSF-derived dendritic cells and osteoclasts. We also tested whether treatment with parathyroid hormone in combination with 1,25D3 would enhance hCAP18 induction as has been reported in skin cells, but we did not find enhancement in any immune cells tested. Our results indicate that hCAP18 is expressed at different levels according to cell type and lineage. Furthermore, potent induction of hCAP18 by 1,25D3 in macrophages and dendritic cells may modulate functions of both innate and adaptive immune cells at sites of infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.