ArticleHereditary cancer in clinical practice2014
Gastric adenomas in familial adenomatous polyposis are common, but subtle, and have a benign course.
Article in Hereditary cancer in clinical practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Japanese society for cancer of the colon and rectum (JSCCR) guidelines 2024 for the clinical practice of hereditary colorectal cancer.International journal of clinical oncology · 2026Guideline
- Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.The British journal of surgery · 2024Guideline
- Guideline
- Longitudinal Surveillance of Gastric Polyposis in Familial Adenomatous Polyposis: Incidence, Progression, and Endoscopic Outcomes.United European gastroenterology journal · 2026Article
- Upper GI polyposis and cancer in FAP: diagnosis, surveillance and treatment.Familial cancer · 2025Review
- Risk factors for dysplastic lesions in the proximal stomach in patients with familial adenomatous polyposis.Endoscopy international open · 2025Article
- Feasibility of underwater endoscopic mucosal resection for endoscopic management of gastric neoplasms in patients with familial adenomatous polyposis.Surgical endoscopy · 2023Article
- Identifying factors associated with detection of sessile gastric polyps in patients with familial adenomatous polyposis.Endoscopy international open · 2022Article
- Prevalence and endoscopic treatment outcomes of upper gastrointestinal neoplasms in familial adenomatous polyposis.Surgical endoscopy · 2022Article
- Article
- Case report expanding the germline AXIN2- related phenotype to include olfactory neuroblastoma and gastric adenoma.BMC medical genetics · 2020Article
- Upper gastrointestinal neoplasia in familial adenomatous polyposis: prevalence, endoscopic features and management.Journal of gastrointestinal oncology · 2019Article
- Use of DNA flow cytometry in the diagnosis, risk stratification, and management of gastric epithelial dysplasia.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Gastric adenocarcinoma and proximal polyposis of the stomach: diagnosis and clinical perspectives.Clinical and experimental gastroenterology · 2018Review
- Gastric tumours in FAP.Familial cancer · 2017Article
- Gastric and duodenal polyps in familial adenomatous polyposis patients: Conventional endoscopyWorld journal of clinical oncology · 2017Article
- Morphology and genetics of pyloric gland adenomas in familial adenomatous polyposis.Histopathology · 2017Article
- Historical Perspective on Familial Gastric Cancer.Cellular and molecular gastroenterology and hepatology · 2017Review
- β-Catenin activation in fundic gland polyps, gastric cancer and colonic polyps in families afflicted by 'gastric adenocarcinoma and proximal polyposis of the stomach' (GAPPS).Journal of clinical pathology · 2016Article
- Clinicopathological features of familial adenomatous polyposis in Korean patients.World journal of gastroenterology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with familial adenomatous polyposis (FAP) are known to have an increased risk for gastric adenomas. The clinical features of gastric adenomas in FAP have not been well characterized, and there is a lack of standardized approaches to the management of these lesions.
aimsTo study the endoscopic appearance, risk factors, clinical course, and response to therapy of gastric adenomas in patients with FAP.
methodsWe retrospectively reviewed the records of 97 patients with FAP who underwent esophagogastroduodenoscopy (EGD) at Mayo Clinic (Florida, Rochester and Arizona) between 2004 and 2013.
resultsNine patients (9%) had biopsy-proven gastric adenomas. Adenomas were located in the antrum (five patients), in the body and fundus in the setting of background fundic gland polyps (FGP) (three patients), and in the body not associated with FGP (one patient). Adenoma size was 3-40 mm and the number of adenomas per patient ranged from one to 20. Adenomas in the antrum were flat and subtle, whereas those in the gastric body or fundus were polypoid and difficult to differentiate from the cystic FGPs seen in patients with FAP. The performing endoscopists reported difficulty with identifying adenomas, and six patients had at least one EGD within the previous three years where gastric adenomas were not reported. Adenomas were classified as tubular in eight patients and tubulovillous in one patient. High grade dysplasia was noted in one patient. After a median follow-up of 63 months (interquartile range: 20-149 months), no patient in our entire cohort (with or without gastric adenomas) developed gastric cancer. The patients in whom gastric adenoma developed, compared to those without gastric adenoma, were more likely to be younger [36 ± 12 vs. 48 ± 15 years, p = 0.02], have concomitant chronic gastritis [22% vs. 0%, p = 0.008], and have desmoid tumors [5 (56%) vs. 19 (22%), p = 0.04].
conclusionsGastric adenomas are not uncommon in patients with FAP and are often difficult to identify endoscopically. Endoscopists should have a high degree of suspicion for gastric adenomas in these patients and a low threshold to biopsy. Given the benign clinical course, recommended initial management is conservative with endoscopic therapy and periodic surveillance.
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