Evidence map›Paper›PMID 24565502›Full record

ArticleEmerging infectious diseases2014

High-level relatedness among Mycobacterium abscessus subsp. massiliense strains from widely separated outbreaks.

Hervé Tettelin, Rebecca M Davidson, Sonia Agrawal, Moira L Aitken, Shamira Shallom, Nabeeh A Hasan, Michael Strong, Vinicius Calado Nogueira de Moura, Mary Ann De Groote, Rafael S Duarte and 12 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 121 citations in OpenAlex.

  1. Canada communicable disease report = Releve des maladies transmissibles au Canada · 2026
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  7. Genomic epidemiology ofERJ open research · 2024
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  8. Evolution towards extremely high β-lactam resistance inbioRxiv : the preprint server for biology · 2024
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  9. Evolution ofVirulence · 2023
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  13. Molecular Epidemiologic Investigation ofAnnals of the American Thoracic Society · 2023
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 2 institutions in 2 countries.

Hervé Tettelin
Rebecca M Davidson
Sonia Agrawal
Moira L Aitken
Shamira Shallom
Nabeeh A Hasan
Michael Strong
Vinicius Calado Nogueira de Moura
Mary Ann De Groote
Rafael S Duarte
Erin Hine
Sushma Parankush
Qi Su
Sean C Daugherty
Claire M Fraser
Barbara A Brown-Elliott
Richard J Wallace
Steven M Holland
Elizabeth P Sampaio
Kenneth N Olivier
Mary Jackson
Adrian M Zelazny
University of Maryland, Baltimore · USUniversidade Federal do Rio de Janeiro · BR

Funding

Bronchiectasis and chronic airway infectionZIAHL006200 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI FENNELLY, KEVIN · 2015 to 2025
$25.1M
Genes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6M
Computational Bioscience Program Training GrantT15LM009451 · NLM · UNIVERSITY OF COLORADO DENVER · PI Katherina Kechris-Mays, Arjun Krishnan · 2007 to 2026
$11.7M
Disinfectant-resistant mycobacteriaR01AI089718 · NIAID · COLORADO STATE UNIVERSITY · PI JACKSON, MARY · 2011 to 2015
$1.8M
Identification of Clinically Important Microbes by Genomic and Proteomic MethodsZIACL080012 · CLC · CLINICAL CENTER · PI ZELAZNY, ADRIAN MARCELO · 2009 to 2025
$0k
Molecular and Virulence Traits of Bacteria & Fungi Causing Persistent InfectionsZIACL080013 · CLC · CLINICAL CENTER · PI ZELAZNY, ADRIAN MARCELO · 2009 to 2025
$0k
Intramural NIH HHSNIAID NIH HHS AI089718NIAID NIH HHS HHSN272200900009CNIAID NIH HHS R01 AI089718NLM NIH HHS 2T15LM009451-06NLM NIH HHS T15 LM009451
6 · The paper itself

Abstract

Three recently sequenced strains isolated from patients during an outbreak of Mycobacterium abscessus subsp. massiliense infections at a cystic fibrosis center in the United States were compared with 6 strains from an outbreak at a cystic fibrosis center in the United Kingdom and worldwide strains. Strains from the 2 cystic fibrosis outbreaks showed high-level relatedness with each other and major-level relatedness with strains that caused soft tissue infections during an epidemic in Brazil. We identified unique single-nucleotide polymorphisms in cystic fibrosis and soft tissue outbreak strains, separate single-nucleotide polymorphisms only in cystic fibrosis outbreak strains, and unique genomic traits for each subset of isolates. Our findings highlight the necessity of identifying M. abscessus to the subspecies level and screening all cystic fibrosis isolates for relatedness to these outbreak strains. We propose 2 diagnostic strategies that use partial sequencing of rpoB and secA1 genes and a multilocus sequence typing protocol.

Indexed as

Disease OutbreaksBrazilCystic FibrosisGenome, BacterialHumansMultilocus Sequence TypingMycobacteriumMycobacterium InfectionsPhylogenyPolymorphism, Single NucleotideUnited KingdomUnited Statesbacteriacystic fibrosisgeographically distant outbreaksMycobacterium abscessusMycobacterium abscessus subsp. massilienseoutbreaksrelatednessstrainstuberculosis and other mycobacteriaUnited KingdomUnited States

Identifiers

PMID24565502
PMCPMC3944860
OpenAlexW2149775609

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.