ArticleAlzheimer's research & therapy2013
Early-onset dementias: diagnostic and etiological considerations.
Article in Alzheimer's research & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Association of high-sensitivity cardiac troponin I levels below the sex-specific 99th percentile with late-life dementia: the Perth Longitudinal Study of Ageing Women.Heart (British Cardiac Society) · 2026Article
- CSF1R mutations in an Italian population of early-onset dementia: a case series.Journal of neurology · 2026Article
- Age at dementia diagnosis, subtype associations, and neuroimaging differentiation in Bangladesh: The CARED study.PloS one · 2026Observational
- Real-world prediction of early-onset dementia by health record data: A multi-center machine learning study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Iron accumulation/overload and Alzheimer's disease risk factors in the precuneus region: A comprehensive narrative review.Aging medicine (Milton (N.S.W)) · 2024Review
- Diverging Relationships among Amyloid, Tau, and Brain Atrophy in Early-Onset and Late-Onset Alzheimer's Disease.Yonsei medical journal · 2024Article
- Association between depression and young-onset dementia in middle-aged women.Alzheimer's research & therapy · 2024Article
- Choriocapillaris reduction accurately discriminates against early-onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Effects of risk factors on the development and mortality of early- and late-onset dementia: an 11-year longitudinal nationwide population-based cohort study in South Korea.Alzheimer's research & therapy · 2024Article
- Tau suppresses microtubule-regulated pancreatic insulin secretion.Molecular psychiatry · 2023Article
- Cognitive impairment following traumatic brain injury in Uganda: Prevalence and associated factors.PLOS global public health · 2023Article
- Microvascular Changes in the Retina Correlate with MRI Markers in Patients with Early-Onset Dementia.Brain sciences · 2022Article
- What do health professionals need to know about young onset dementia? An international Delphi consensus study.BMC health services research · 2022Article
- Identification of Early Onset Dementia in Population-Based Health Administrative Data: A Validation Study Using Primary Care Electronic Medical Records.Journal of Alzheimer's disease : JAD · 2022Article
- Early-onset dementia: key issues using a relationship-centred care approach.Postgraduate medical journal · 2021Review
- Risk of early-onset dementia among persons with tinnitus: a retrospective case-control study.Scientific reports · 2021Article
- Potential Virus Involvement in Alzheimer's Disease: Results from a Phase IIa Trial Evaluating Apovir, an Antiviral Drug Combination.Journal of Alzheimer's disease reports · 2021Article
- An Integrative Literature Review on the Nomenclature and Definition of Dementia at a Young Age.Journal of Alzheimer's disease : JAD · 2021Review
- A novel SNCA E83Q mutation in a case of dementia with Lewy bodies and atypical frontotemporal lobar degeneration.Neuropathology : official journal of the Japanese Society of Neuropathology · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper summarizes the body of literature about early-onset dementia (EOD) that led to recommendations from the Fourth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia. A broader differential diagnosis is required for EOD compared with late-onset dementia. Delays in diagnosis are common, and the social impact of EOD requires special care teams. The etiologies underlying EOD syndromes should take into account family history and comorbid diseases, such as cerebrovascular risk factors, that may influence the clinical presentation and age at onset. For example, although many EODs are more likely to have Mendelian genetic and/or metabolic causes, the presence of comorbidities may drive the individual at risk for late-onset dementia to manifest the symptoms at an earlier age, which contributes further to the observed heterogeneity and may confound diagnostic investigation. A personalized medicine approach to diagnosis should therefore be considered depending on the age at onset, clinical presentation, and comorbidities. Genetic counseling and testing as well as specialized biochemical screening are often required, especially in those under the age of 40 and in those with a family history of autosomal dominant or recessive disease. Novel treatments in the drug development pipeline for EOD, such as genetic forms of Alzheimer's disease, should target the specific pathogenic cascade implicated by the mutation or biochemical defect.
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Registered trials
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