Trial reportThe journal of allergy and clinical immunology. In practice2013
Biologic mechanisms of environmental tobacco smoke in children with poorly controlled asthma: results from a multicenter clinical trial.
Trial report in The journal of allergy and clinical immunology. In practice, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Inhaled corticosteroids in children with persistent asthma: dose-response effects on growth.The Cochrane database of systematic reviews · 2014Pooled it
- Factors associated with high short-acting β2-agonist use in urban children with asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2015Trial
- Improving Care of Inner-City Children with Poorly Controlled Asthma: What Mothers Want You to Know.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersTrial
- Very Poorly Controlled Asthma in Urban Minority Children: Lessons Learned.The journal of allergy and clinical immunology. In practiceTrial
- Influence of Magnesium Status on the Association of Tobacco Exposure With Depression in Old Patients With Heart Failure: A Cross-Sectional Study of the NHANES Database.Cardiovascular therapeutics · 2026Article
- The joint effect of vitamin-D status and tobacco exposure on overweight and obesity in children.The British journal of nutrition · 2024Article
- Effect of dietary antioxidant quality score on tobacco smoke exposure and asthma in children and adolescents: a cross-sectional study from the NHANES database.BMC pediatrics · 2024Article
- NHANES-based analysis of the correlation between leisure-time physical activity, serum cotinine levels and periodontitis risk.BMC oral health · 2024Article
- Untargeted Urinary Metabolomics and Children's Exposure to Secondhand Smoke: The Influence of Individual Differences.International journal of environmental research and public health · 2021Article
- A Mobile Health Intervention for Adolescents Exposed to Secondhand Smoke: Pilot Feasibility and Efficacy Study.JMIR formative research · 2020Article
- Influence of Second-Hand Smoke and Prenatal Tobacco Smoke Exposure on Biomarkers, Genetics and Physiological Processes in Children-An Overview in Research Insights of the Last Few Years.International journal of environmental research and public health · 2020Review
- Exacerbation-Prone Asthma.The journal of allergy and clinical immunology. In practice · 2020Article
- Viruses and non-allergen environmental triggers in asthma.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2019Review
- Association between second hand smoke (SHS) exposure and caregiver stress in children with poorly controlled asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2019Article
- Quenching the fires: Pro-resolving mediators, air pollution, and smoking.Pharmacology & therapeutics · 2019Review
- Biomarkers in asthma: state of the art.Asthma research and practice · 2018Review
- Difficult vs. Severe Asthma: Definition and Limits of Asthma Control in the Pediatric Population.Frontiers in pediatrics · 2018Review
- Severe asthma in school-age children: evaluation and phenotypic advances.Current allergy and asthma reports · 2015Review
- Sources and Biomarkers of Secondhand Tobacco Smoke Exposure in Urban Adolescents.Academic pediatricsArticle
- Provider Counseling About Secondhand Smoke Exposure for Urban Children With Persistent or Poorly Controlled Asthma.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & PractitionersArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundEnvironmental tobacco smoke (ETS) negatively affects children with asthma. The prevalence of ETS exposure among children with poor asthma control may be changing. Importantly, the mechanisms by which ETS worsens asthma control are poorly understood.
objectiveWe describe how ETS affects gastroesophageal reflux (GER), respiratory infections, and leukotriene production among children with poor asthma control.
methodsWe analyzed data from 306 children between 6 and 17 years of age with poorly controlled asthma enrolled in a 6-month clinical trial. We evaluated prevalence and determinants of ETS exposure by interview, questionnaire, and urinary cotinine and the association of ETS exposure on leukotriene production, respiratory infections, GER, lung function, and asthma control. We used multivariable linear, logistic, and Poisson regressions to assess outcomes.
resultsETS prevalence estimates ranged from 6% to 30%. Children with domestic indoor exposure had worse asthma control (c-Asthma Control Test, 17.8 vs 21.5; P = .04), worse FEV1 % predicted (84.1 vs 90.7; P = .02), and a trend for increased mean urinary leukotriene E4. ETS from any setting was associated with increased symptomatic respiratory infections (adjusted incidence rate ratio: 1.30; P = .02). However, children exposed to ETS did not have symptoms or pH probe results, suggestive of heightened GER.
conclusionsDomestic smoking exposure was associated with both higher rates of symptomatic respiratory infection and poorer asthma control despite generally intensive controller therapy. ETS exposure is common among asthmatic children with poor control and may worsen asthma control by promoting respiratory infections. Further investigation is required to elucidate ETS mechanisms in poor asthma control.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.