ArticleJournal of the American Academy of Child and Adolescent Psychiatry2014
White matter abnormalities and cognitive impairment in early-onset schizophrenia-spectrum disorders.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Measuring white matter microstructure in 1,457 cannabis users and 1,441 controls: A systematic review of diffusion-weighted MRI studies.Frontiers in neuroimaging · 2023Pooled it
- White matter integrity in individuals at ultra-high risk for psychosis: a systematic review and discussion of the role of polyunsaturated fatty acids.BMC psychiatry · 2016Pooled it
- Exploring white matter microstructure and the impact of antipsychotics in adolescent-onset psychosis.PloS one · 2020Trial
- Targeting enhancing myelin regeneration reverses cognitive deficits in a mouse model of intellectual disability.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Exploring the Pathways Between Early Auditory Processing, Processing Speed, Social Cognition, and Negative Symptoms on Social Functioning in Individuals at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach.Biological psychiatry · 2026Article
- Shared and distinct white matter abnormalities in adolescent-onset schizophrenia and adolescent-onset psychotic bipolar disorder.Psychological medicine · 2023Article
- Identification of texture MRI brain abnormalities on first-episode psychosis and clinical high-risk subjects using explainable artificial intelligence.Translational psychiatry · 2022Article
- White matter alterations and the conversion to psychosis: A combined diffusion tensor imaging and glutamateSchizophrenia research · 2022Article
- Microstructural changes along the cingulum in young adolescents with psychotic experiences: An along-tract analysis.The European journal of neuroscience · 2022Article
- White matter microstructure of superior longitudinal fasciculus II is associated with intelligence and treatment response of negative symptoms in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Relationship between White Matter Alterations and Pathophysiological Symptoms in Patients with Ultra-High Risk of Psychosis, First-Episode, and Chronic Schizophrenia.Brain sciences · 2022Article
- Associations of Neurocognition and Social Cognition With Brain Structure and Function in Early-Onset Schizophrenia.Frontiers in psychiatry · 2022Article
- White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis.Molecular psychiatry · 2021Article
- The impact of susceptibility correction on diffusion metrics in adolescents.Pediatric radiology · 2021Article
- Disturbances in White Matter Integrity in the Ultra-High-Risk Psychosis State-A Systematic Review.Journal of clinical medicine · 2021Review
- White matter brain aging in relationship to schizophrenia and its cognitive deficit.Schizophrenia research · 2021Article
- Adolescent Neurodevelopment and Vulnerability to Psychosis.Biological psychiatry · 2021Review
- Cognitive Implications of Correlated Structural Network Changes in Schizophrenia.Frontiers in integrative neuroscience · 2021Article
- Altered microstructural pattern of white matter in Cushing's disease identified by automated fiber quantification.NeuroImage. Clinical · 2021Article
- Glucose disturbances, cognitive deficits and white matter abnormalities in first-episode drug-naive schizophrenia.Molecular psychiatry · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo characterize white matter abnormalities in adolescents with early-onset schizophrenia (EOS) relative to 3 comparison groups (adolescents at clinical high risk for developing schizophrenia [CHR], adolescents with cannabis use disorder [CUD], and healthy controls [HC]), and to identify neurocognitive correlates of white matter abnormalities in EOS.
methodWe used diffusion tensor imaging and tractography methods to examine fractional anisotropy (FA) of the cingulum bundle, superior longitudinal fasciculus, corticospinal tract (CST), inferior longitudinal fasciculus (ILF), inferior fronto-occipital fasciculus (IFOF), and uncinate fasciculus in adolescents with EOS (n = 55), CHR (n = 21), CUD (n = 31), and HC (n = 55). FA in tracts that were significantly altered in EOS was correlated with neurocognitive performance.
resultsEOS and CHR groups had significantly lower FA than HC in 4 tracts, namely, bilateral CST, left ILF, and left IFOF. CUD had lower FA than HC in left IFOF. Lower FA in left IFOF and left ILF predicted worse neurocognitive performance in EOS.
conclusionsThis study identified white matter abnormalities of the left ILF and left IFOF as possible biomarkers of vulnerability for developing schizophrenia. Lower FA in these tracts may disrupt functioning of ventral visual and language streams, producing domain-specific neurocognitive deficits that interfere with higher-order cognitive abilities.
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