Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2014
24- and 36-week outcomes for the Child/Adolescent Anxiety Multimodal Study (CAMS).
Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 61 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Child/Adolescent Anxiety Multimodal Treatment Study
Partners in Caring for Anxious Youth
Who cites it
61 citing papers in PubMed, 6 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- The current state-of-the-art in pharmacotherapy for pediatric generalized anxiety disorder.Expert opinion on pharmacotherapy · 2023Pooled it
- Cognitive behavioural therapy for anxiety disorders in children and adolescents.The Cochrane database of systematic reviews · 2020Pooled it
- A History of Child and Adolescent Treatment Through a Distillation Lens: Looking Back to Move Forward.The journal of behavioral health services & research · 2020Pooled it
- Antidepressant Treatment Duration in Pediatric Depressive and Anxiety Disorders: How Long is Long Enough?Current problems in pediatric and adolescent health care · 2018Pooled it
- Comparative Effectiveness and Safety of Cognitive Behavioral Therapy and Pharmacotherapy for Childhood Anxiety Disorders: A Systematic Review and Meta-analysis.JAMA pediatrics · 2017Pooled it
- Generalised anxiety disorder in children and adolescents.BMJ clinical evidence · 2016Pooled it
- Remission, Recovery, Relapse, and Recurrence Rates for Suicide Attempts and Nonsuicidal Self-Injury for Suicidal Youth Treated With Dialectical Behavior Therapy or Supportive Therapy.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Trial
- Trial
- A Sequential Multiple Assignment Randomized Trial (SMART) study of medication and CBT sequencing in the treatment of pediatric anxiety disorders.BMC psychiatry · 2021Trial
- Brief Behavioral Therapy for Pediatric Anxiety and Depression in Primary Care: A Follow-up.Journal of the American Academy of Child and Adolescent Psychiatry · 2020Trial
- Controlled trial of lovastatin combined with an open-label treatment of a parent-implemented language intervention in youth with fragile X syndrome.Journal of neurodevelopmental disorders · 2020Trial
- A randomised controlled trial of treatments of childhood anxiety disorder in the context of maternal anxiety disorder: clinical and cost-effectiveness outcomes.Journal of child psychology and psychiatry, and allied disciplines · 2020Trial
- The Impact of Treatment Expectations on Exposure Process and Treatment Outcome in Childhood Anxiety Disorders.Journal of abnormal child psychology · 2020Trial
- Do Immediate Gains Predict Long-Term Symptom Change? Findings from a Randomized Trial of a Single-Session Intervention for Youth Anxiety and Depression.Child psychiatry and human development · 2019Trial
- Results from the Child/Adolescent Anxiety Multimodal Longitudinal Study (CAMELS): Functional outcomes.Journal of consulting and clinical psychology · 2018Trial
- Establishing Clinical Cutoffs for Response and Remission on the Screen for Child Anxiety Related Emotional Disorders (SCARED).Journal of the American Academy of Child and Adolescent Psychiatry · 2017Trial
- Placebo Response in Pediatric Anxiety Disorders: Results from the Child/Adolescent Anxiety Multimodal Study.Journal of child and adolescent psychopharmacology · 2017Trial
- Clinical outcomes and cost-effectiveness of brief guided parent-delivered cognitive behavioural therapy and solution-focused brief therapy for treatment of childhood anxiety disorders: a randomised controlled trial.The lancet. Psychiatry · 2017Trial
- Parental psychopathology and treatment outcome for anxious youth: roles of family functioning and caregiver strain.Journal of consulting and clinical psychology · 2015Trial
- Improving Transition to Adulthood for Students with Autism: A Randomized Controlled Trial of STEPS.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Trial
1 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
17 authors at 10 institutions in 2 countries.
Funding
Abstract
objectiveWe report active treatment group differences on response and remission rates and changes in anxiety severity at weeks 24 and 36 for the Child/Adolescent Anxiety Multimodal Study (CAMS).
methodCAMS youth (N = 488; 74% ≤ 12 years of age) with DSM-IV separation, generalized, or social anxiety disorder were randomized to 12 weeks of cognitive-behavioral therapy (CBT), sertraline (SRT), CBT+SRT (COMB), or medication management/pill placebo (PBO). Responders attended 6 monthly booster sessions in their assigned treatment arm; youth in COMB and SRT continued on their medication throughout this period. Efficacy of COMB, SRT, and CBT (n = 412) was assessed at 24 and 36 weeks postrandomization. Youth randomized to PBO (n = 76) were offered active CAMS treatment if nonresponsive at week 12 or over follow-up and were not included here. Independent evaluators blind to study condition assessed anxiety severity, functioning, and treatment response. Concomitant treatments were allowed but monitored over follow-up.
resultsThe majority (>80%) of acute responders maintained positive response at both weeks 24 and 36. Consistent with acute outcomes, COMB maintained advantage over CBT and SRT, which did not differ, on dimensional outcomes; the 3 treatments did not differ on most categorical outcomes over follow-up. Compared to COMB and CBT, youth in SRT obtained more concomitant psychosocial treatments, whereas those in SRT and CBT obtained more concomitant combined (medication plus psychosocial) treatment.
conclusionsCOMB maintained advantage over CBT and SRT on some measures over follow-up, whereas the 2 monotherapies remained indistinguishable. The observed convergence of COMB and monotherapy may be related to greater use of concomitant treatment during follow-up among youth receiving the monotherapies, although other explanations are possible. Although outcomes were variable, most CAMS-treated youth experienced sustained treatment benefit. Clinical trial registration information-Child and Adolescent Anxiety Disorders (CAMS); URL: http://clinicaltrials.gov. Unique identifier: NCT00052078.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.