Evidence map›Paper›PMID 24565336›Full record

ReviewStem cell research & therapy2013

A human pluripotent stem cell platform for assessing developmental neural toxicity screening.

Zhonggang Hou, Jue Zhang, Michael P Schwartz, Ron Stewart, C David Page, William L Murphy, James A Thomson

Open access · goldAbstract readReview
In one paragraph

Review in Stem cell research & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. The Application of Brain Organoids in Assessing Neural Toxicity.Frontiers in molecular neuroscience · 2022
    Review
  3. Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021
    Review
  4. Prospects and Frontiers of Stem Cell Toxicology.Stem cells and development · 2017
    Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zhonggang Hou
Jue Zhang
Michael P Schwartz
Ron Stewart
C David Page
William L Murphy
James A Thomson
University of Wisconsin–Madison · USMorgridge Institute for Research · US

Funding

Retinal tissue chips for ocular disease modelingUH3TR000506 · NCATS · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI THOMSON, JAMES ALEXANDER · 2014 to 2016
$6.2M
Human iPS/ES Cell-Based Models for Predictive Neural Toxicity and TeratogenicityUH2TR000506 · NCATS · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI THOMSON, JAMES ALEXANDER · 2012 to 2013
$2.4M
NCATS NIH HHS 1UH2TR000506-01NCATS NIH HHS UH2 TR000506NCATS NIH HHS UH3 TR000506
6 · The paper itself

Abstract

A lack of affordable and effective testing and screening procedures mean surprisingly little is known about the health hazards of many of the tens of thousands of chemicals in use in the world today. The recent rise in the number of children affected by neurological disorders such as autism has stirred valuable debate about the role chemicals play in our daily life, highlighting the need for improved methods of assessing chemicals for developmental neural toxicity.

Indexed as

AnimalsGene Expression ProfilingHumansHydrogelsMicrofluidic Analytical TechniquesMicrogliaNeurogenesisPericytesPluripotent Stem CellsToxins, BiologicalHydrogelsToxins, Biological

Identifiers

PMID24565336
PMCPMC3983661
OpenAlexW2155516775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.