ArticlePflugers Archiv : European journal of physiology1988
Evidence for two calcium currents in insulin-secreting cells.
Article in Pflugers Archiv : European journal of physiology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 67 citations in OpenAlex.
- Beta-Cell Ion Channels and Their Role in Regulating Insulin Secretion.Comprehensive Physiology · 2021Review
- Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells.The Journal of biological chemistry · 2015Article
- Induction of pancreatic duct cells of neonatal rats into insulin-producing cells with fetal bovine serum: a natural protocol and its use for patch clamp experiments.World journal of gastroenterology · 2005Article
- Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications.Journal of bioenergetics and biomembranes · 2003Review
- Low-voltage-activated ("T-Type") calcium channels in review.Journal of bioenergetics and biomembranes · 2003Review
- Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans.Endocrine · 2000Review
- The phantom burster model for pancreatic beta-cells.Biophysical journal · 2000Article
- Dynamical complexity and temporal plasticity in pancreatic beta-cells.Journal of biosciences · 2000Review
- Modulation of the bursting properties of single mouse pancreatic beta-cells by artificial conductances.Biophysical journal · 1999Article
- Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate, and GABA transmit?Endocrine · 1998Review
- A single non-L-, non-N-type Ca2+ channel in rat insulin-secreting RINm5F cells.Pflugers Archiv : European journal of physiology · 1996Article
- Voltage-dependent Na+ and Ca2+ currents in human pancreatic islet beta-cells: evidence for roles in the generation of action potentials and insulin secretion.Pflugers Archiv : European journal of physiology · 1995Article
- A role for calcium release-activated current (CRAC) in cholinergic modulation of electrical activity in pancreatic beta-cells.Biophysical journal · 1995Article
- Block of non-L-, non-N-type Ca2+ channels in rat insulinoma RINm5F cells by omega-agatoxin IVA and omega-conotoxin MVIIC.Pflugers Archiv : European journal of physiology · 1995Article
- Correlations of rates of insulin release from islets and plateau fractions for beta-cells.Bulletin of mathematical biology · 1995Article
- Voltage-independent calcium channels mediate slow oscillations of cytosolic calcium that are glucose dependent in pancreatic beta-cells.Endocrinology · 1994Article
- Inactivation of HIT cell Ca2+ current by a simulated burst of Ca2+ action potentials.Biophysical journal · 1994Article
- Inactivation of voltage-dependent calcium current in an insulinoma cell line.European biophysics journal : EBJ · 1994Article
- Sensitivity to dihydropyridines, omega-conotoxin and noradrenaline reveals multiple high-voltage-activated Ca2+ channels in rat insulinoma and human pancreatic beta-cells.Pflugers Archiv : European journal of physiology · 1993Article
- Cytoplasmic calcium transients due to single action potentials and voltage-clamp depolarizations in mouse pancreatic B-cells.The EMBO journal · 1992Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Inward currents were measured in cultured rat pancreatic islet cells using the whole-cell patch-clamp technique. Depolarization elicited both transient and more sustained inward currents. The transient current was blocked by external Na removal, TTX or depolarizing holding potentials while the sustained current was blocked by external Ca removal or the addition of Co, Ni or Cd ions to the external solution. Replacing Ca with Ba increased the amplitude of the sustained current and decreased its rate of decay. These results suggest that the transient current was due to the activation of Na channels while the sustained current was mediated by Ca channels. Two characteristics of the data suggested that two Ca currents may contribute to the sustained current. First, a second shoulder, or hump, was observed on the descending limb of the Ca current I-V of many cells, suggesting that they may possess two Ca channels that activate at different voltages. Second, the low and high voltage components of the I-V were differentially suppressed by Cd. Neither of the Ca current components was very sensitive to the Ca channel agonist BAY K 8644. These results were confirmed in HIT cells, another insulin-secreting preparation.
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