ArticleVirology journal2014
Muscovy duck reovirus p10.8 protein localizes to the nucleus via a nonconventional nuclear localization signal.
Article in Virology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Importin Alpha Is Implicated in the Nuclear Import of Novel Duck Reovirus Protein p18.Viruses · 2026Article
- Viral Proteins as Emerging Cancer Therapeutics.Cancers · 2021Review
- Endoplasmic Reticulum Stress Mediated MDRV p10.8 Protein-Induced Cell Cycle Arrest and Apoptosis Through the PERK/eIF2α Pathway.Frontiers in microbiology · 2018Article
- Analysis of differentially expressed proteins in Muscovy duck embryo fibroblasts infected with virulent and attenuated Muscovy duck reovirus by two-dimensional polyacrylamide gel electrophoresis.The Journal of veterinary medical science · 2017Article
- Mapping a Type-specific Epitope by Monoclonal Antibody against VP3 Protein of Duck Hepatitis A Type 1 Virus.Scientific reports · 2017Article
- Muscovy duck reovirus σNS protein triggers autophagy enhancing virus replication.Virology journal · 2017Article
- Identification of a conserved B-cell epitope on duck hepatitis A type 1 virus VP1 protein.PloS one · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt was previously report that the first open reading frame of Muscovy duck reocvirus S4 gene encodes a 95-amino-acid protein, designed p10.8, which has no sequence similarity to other known proteins. Its amino acid sequence offers no clues about its function.
resultsSubcellular localization and nuclear import signal of p10.8 were characterized. We found that p10.8 protein localizes to the nucleus of infected and transfected cells, suggesting that p10.8 nuclear localization is not facilitated by viral infection or any other viral protein. A functional non-canonical nuclear localization signal (NLS) for p10.8 was identified and mapped to N-terminus residues 1-40. The NLS has the ability to retarget a large cytoplasmic protein to the nucleus.
conclusionsp10.8 imported into the nucleus might via a nonconventional signal nuclear signal.
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